Entry Detail

General Information

Database ID: LDA0003966
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:EGFR-AS1
Full Name:EGFR antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):55179750End Site(bp):55188949
External Links:
Ensembl ID:ENSG00000224057
Ensembl Transcript ID:N/A
Entrez Gene:100507500.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Kidney Neoplasms  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Esophageal Squamous Cell Carcinoma  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:263D007680
Disease Name:kidney cancerKidney Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A urinary system cancer that is located_in the kidney.Tumors or cancers of the KIDNEY.
Alias:malignant neoplasm of kidney except pelvis//malignant tumour of kidney//renal cancerKidney Neoplasms//Kidney Neoplasm//Neoplasm, Kidney//Renal Neoplasms//Neoplasm, Renal//Neoplasms, Renal//Renal Neoplasm//Neoplasms, Kidney//Cancer of Kidney//Kidney Cancers//Renal Cancer//Cancer, Renal//Cancers, Renal//Renal Cancers//Cancer of the Kidney//Kidney Cancer//Cancer, Kidney//Cancers, Kidney

 

Disease Association Statistics

Total Associated ncRNA Number:20   
More Information
Causal ncRNA Number:16
Network:
Top Causal ncRNAs:
LINC01852-201  (Score: 0.731059)
EGFR-AS1  (Score: 0.731059)
DUXAP9  (Score: 0.731059)
circTXNDC11  (Score: 0.731059)
hsa_circ_0065217  (Score: 0.731059)
circCYP24A1  (Score: 0.731059)
circKL  (Score: 0.731059)
TCL6  (Score: 0.731059)
LINC01852-201  (Score: 0.731059)
EGFR-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//RNA Pull-Down
Weak Evidence:

 

Reference

[1] PubMed ID:30770799
Disease Name:Kidney Neoplasms
Sample:RCC tissues
Dysfunction Pattern:Expression[highly expressed]
Validated Method:qRT-PCR//RNA Pull-Down
Description:In our validation cohort (n = 204), EGFR-AS1 was significantly upregulated in RCC tissues (P < 0.001).
Causality:Yes
Causal Description:Gain-of-function and loss-of-function studies showed that EGFR-AS1 promoted cell proliferation and invasion in vitro and in vivo.
Clinical-realted Application:Multivariate analysis suggested that higher EGFR-AS1 expression predicted a poor prognosis in RCC patients (high vs low: P = 0.018, HR = 2.204, 95% CI: 1.145-4.241).