Entry Detail

General Information

Database ID: LDA0004019
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DUXAP9
Full Name:double homeobox A pseudogene 9
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC01296|LNMAT1
Chromosome:14
Strand:+
Coordinate:
Start Site(bp):19062377End Site(bp):19107497
External Links:
Ensembl ID:ENSG00000225210
Ensembl Transcript ID:N/A
Entrez Gene:503638.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:22
Network:
Top Causal Diseases:
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Neuroblastoma  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.999893)
Neuroblastoma  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:263D007680
Disease Name:kidney cancerKidney Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A urinary system cancer that is located_in the kidney.Tumors or cancers of the KIDNEY.
Alias:malignant neoplasm of kidney except pelvis//malignant tumour of kidney//renal cancerKidney Neoplasms//Kidney Neoplasm//Neoplasm, Kidney//Renal Neoplasms//Neoplasm, Renal//Neoplasms, Renal//Renal Neoplasm//Neoplasms, Kidney//Cancer of Kidney//Kidney Cancers//Renal Cancer//Cancer, Renal//Cancers, Renal//Renal Cancers//Cancer of the Kidney//Kidney Cancer//Cancer, Kidney//Cancers, Kidney

 

Disease Association Statistics

Total Associated ncRNA Number:20   
More Information
Causal ncRNA Number:16
Network:
Top Causal ncRNAs:
LINC01852-201  (Score: 0.731059)
EGFR-AS1  (Score: 0.731059)
DUXAP9  (Score: 0.731059)
circTXNDC11  (Score: 0.731059)
hsa_circ_0065217  (Score: 0.731059)
circCYP24A1  (Score: 0.731059)
circKL  (Score: 0.731059)
TCL6  (Score: 0.731059)
LINC01852-201  (Score: 0.731059)
EGFR-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Wound Healing Assay//Flow Cytometry//CCK8//FISH//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34168980
Disease Name:Kidney Neoplasms
Sample:112 pairs of localized ccRCC tumor tissues
Dysfunction Pattern:Regulation(IGF2BP2/PI3K/AKT )
Validated Method:RNA Pull-Down//Wound Healing Assay//Flow Cytometry//FISH//CCK8//Colony Formation Assay
Description:In this study, we characterized a lncRNA DUXAP9 and the upregulation of DUXAP9 was analyzed by quantitative real-time PCR in 112 pairs of localized ccRCC tumor tissues compared with adjacent normal tissues. Pull-down, RNA immunoprecipitation and RNA stability assays (involving actinomycin D) showed that DUXAP9 was methylated at N6-adenosine and binds to IGF2BP2, which increases its stability. DUXAP9 activate PI3K/AKT pathway and Snail expression in renal cancer cells.
Causality:Yes
Causal Description:DUXAP9 knockdown in renal cancer cells inhibited renal cancer cells proliferation and motility capacities in vitro and reversed epithelial-mesenchymal transition (EMT), whereas overexpression of DUXAP9 promoted renal cancer cells proliferation and motility capacities in vitro and induced EMT.
Clinical-realted Application:DUXAP9 expression was an independent risk factor for poor prognosis in localized ccRCC (p<0.05).