Entry Detail

General Information

Database ID: LDA0004047
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DDX21
Full Name:DExD-box helicase 21
Category:LncRNA
Species:Homo sapiens
Synonyms:GUA|GURDB|II/Gu|RH|RH II/Gu|RH-II/GU|RH-II/GuA|gu-alpha
Chromosome:10
Strand:+
Coordinate:
Start Site(bp):68956170End Site(bp):68985068
External Links:
Ensembl ID:ENSG00000165732
Ensembl Transcript ID:N/A
Entrez Gene:9188.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1612D001943
Disease Name:breast cancerBreast Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A thoracic cancer that originates in the mammary gland.Tumors or cancer of the human BREAST.
Alias:breast tumor//malignant neoplasm of breast//malignant tumor of the breast//mammary cancer//mammary tumor//primary breast cancerBreast Neoplasms//Breast Neoplasm//Neoplasm, Breast//Breast Tumors//Breast Tumor//Tumor, Breast//Tumors, Breast//Neoplasms, Breast//Breast Cancer//Cancer, Breast//Mammary Cancer//Cancer, Mammary//Cancers, Mammary//Mammary Cancers//Malignant Neoplasm of Breast//Breast Malignant Neoplasm//Breast Malignant Neoplasms//Malignant Tumor of Breast//Breast Malignant Tumor//Breast Malignant Tumors//Cancer of Breast//Cancer of the Breast//Mammary Carcinoma, Human//Carcinoma, Human Mammary//Carcinomas, Human Mammary//Human Mammary Carcinomas//Mammary Carcinomas, Human//Human Mammary Carcinoma//Mammary Neoplasms, Human//Human Mammary Neoplasm//Human Mammary Neoplasms//Neoplasm, Human Mammary//Neoplasms, Human Mammary//Mammary Neoplasm, Human//Breast Carcinoma//Breast Carcinomas//Carcinoma, Breast//Carcinomas, Breast

 

Disease Association Statistics

Total Associated ncRNA Number:1186   
More Information
Causal ncRNA Number:766
Network:
Top Causal ncRNAs:
MILIP  (Score: 1)
GAS5  (Score: 1)
MILIP  (Score: 1)
H19  (Score: 1)
CDKN2B-AS1  (Score: 1)
DANCR  (Score: 1)
AFAP1-AS1  (Score: 1)
CDKN2B-AS1  (Score: 1)
NEAT1  (Score: 1)
circHIPK3  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Transwell Assay//Wound Healing Assay//Colony Formation Assay//qRT-PCR//FISH//Luciferase Report Assay//IHC//IF
Weak Evidence:

 

Reference

[1] PubMed ID:35522944
Disease Name:Breast Neoplasms
Sample:BC cell lines
Dysfunction Pattern:Interaction(miR‐1264/QKI axis)
Validated Method:In Vivo Experiment//RNA Pull-Down//IHC//Western Blot//Wound Healing Assay//qRT-PCR//FISH//IF//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:CircDDX21 expression was downregulated in the normal mammary gland cell line MCF10A compared with other BC cell lines
Causality:Yes
Causal Description: Overexpression of circDDX21 repressed the proliferation, migration, invasion and clone formation abilities of the two TNBC cell lines, whereas circDDX21 knockdown promoted these abilities
Clinical-realted Application: Interestingly, low expression of circDDX21 indicated prolonged survival in TNBC patients