Entry Detail

General Information

Database ID: LDA0004068
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DANCR
Full Name:Angelman syndrome chromosome region
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
External Links:
Ensembl ID:ENSG00000226950
Ensembl Transcript ID:N/A
Entrez Gene:282.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:62   
More Information
Causal Disease Number:54
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Pancreatic Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Colorectal Neoplasms  (Score: 1)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3347D012516
Disease Name:osteosarcomaOsteosarcoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A bone sarcoma that is located_in bone that has_material_basis_in cells of mesenchymal origin.A sarcoma originating in bone-forming cells, affecting the ends of long bones. It is the most common and most malignant of sarcomas of the bones, and occurs chiefly among 10- to 25-year-old youths. (From Stedman, 25th ed)
Alias:Osteogenic sarcoma//Skeletal sarcoma//bone tissue neoplasm//osteoid sarcomaOsteosarcoma//Osteosarcomas//Osteosarcoma Tumor//Osteosarcoma Tumors//Tumor, Osteosarcoma//Tumors, Osteosarcoma//Sarcoma, Osteogenic//Osteogenic Sarcomas//Sarcomas, Osteogenic//Osteogenic Sarcoma

 

Disease Association Statistics

Total Associated ncRNA Number:656   
More Information
Causal ncRNA Number:600
Network:
Top Causal ncRNAs:
NEAT1  (Score: 1)
PVT1  (Score: 1)
GAS5  (Score: 1)
SNHG16  (Score: 1)
LINC00662  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
LINC00662  (Score: 1)
ZFAS1  (Score: 1)
TUG1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31727012
Disease Name:Osteosarcoma
Sample:OS tissues,cell lines
Dysfunction Pattern:Interaction[p38MAPK signalling pathway]
Validated Method:CCK8//qRT-PCR//EdU Staining//Transwell Assay
Description:ANCR was up-regulated in OS cells and tissues.Inhibition of the p38MAPK signalling pathway (SB203580) in MG-63 and U2OS cells rescued si-ANCR-induced inhibition of cell migration and invasion.
Causality:Yes
Causal Description:ANCR silencing significantly inhibited the proliferation rate, decreased the percentage of migration and invasion cells, down-regulated N-cadherin, and up-regulated E-cadherin and p-p38MAPK in MG-63 and U2OS cells.
Clinical-realted Application:

[2] PubMed ID:32633342
Disease Name:Osteosarcoma
Sample:osteosarcoma tissue and cells
Dysfunction Pattern:regulation[miR-149/MSI2 axis]
Validated Method:qRT-PCR//Western Blot//Transwell Assay
Description:DANCR was significantly up-regulated in both osteosarcoma tissue and cells.It may be used as a potential target in the treatment of osteosarcoma in the future, by targeting the miR-149/MSI2 axis to regulate the occurrence and development of osteosarcoma.
Causality:Yes
Causal Description:DANCR can significantly reduce the migration and invasion of osteosarcoma cells.
Clinical-realted Application:The high expression of DANCR was significantly positively correlated with tissue typing and advanced TNM stage.