Entry Detail

General Information

Database ID: LDA0004091
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DLEU2
Full Name:deleted in lymphocytic leukemia 2
Category:LncRNA
Species:Homo sapiens
Synonyms:ALT1|BCMSUN|DLB2|LEU2|LINC00022|MIR15AHG|NCRNA00022|RFP2|RFP2OS|TRIM13OS
Chromosome:13
Strand:-
Coordinate:
Start Site(bp):49982549End Site(bp):50125541
External Links:
Ensembl ID:ENSG00000231607
Ensembl Transcript ID:N/A
Entrez Gene:8847.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:36   
More Information
Causal Disease Number:28
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D013964
Disease Name:Thyroid Neoplasms
Category:MeSH
Type:Neoplasms
Define:Tumors or cancer of the THYROID GLAND.
Alias:Thyroid Neoplasms//Neoplasm, Thyroid//Thyroid Neoplasm//Neoplasms, Thyroid//Thyroid Carcinoma//Carcinoma, Thyroid//Carcinomas, Thyroid//Thyroid Carcinomas//Cancer of Thyroid//Thyroid Cancers//Thyroid Cancer//Cancer, Thyroid//Cancers, Thyroid//Cancer of the Thyroid//Thyroid Adenoma//Adenoma, Thyroid//Adenomas, Thyroid//Thyroid Adenomas

 

Disease Association Statistics

Total Associated ncRNA Number:178   
More Information
Causal ncRNA Number:170
Network:
Top Causal ncRNAs:
hsa_circ_0067934  (Score: 0.999893)
TMC6  (Score: 0.999893)
TMC6  (Score: 0.999893)
hsa_circ_0067934  (Score: 0.999893)
HOTAIRM1  (Score: 0.985791)
H19  (Score: 0.985791)
NORAD  (Score: 0.985791)
PVT1  (Score: 0.985791)
CASC2  (Score: 0.985791)
hsa_circ_0058124  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33764889
Disease Name:Thyroid Neoplasms
Sample:thyroid cancer tissues and cell lines
Dysfunction Pattern:Interaction(miR-205-5p/TNFAIP8 axis)
Validated Method:In Vivo Experiment//Western Blot//Transfection//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Bioinformatics Analysis//Transwell Assay
Description:DLEU2 and tumor necrosis factor-α-induced protein 8 (TNFAIP8) were highly expressed in thyroid cancer tissues and cell lines. DLEU2/miR-205-5p/TNFAIP8 signaling axis was identified in thyroid cancer cells.
Causality:Yes
Causal Description:DLEU2 and TNRAIP8 promoted the proliferation, migration and aerobic glycolysis and restrained the apoptosis of thyroid cancer cells.
Clinical-realted Application: