Entry Detail

General Information

Database ID: LDA0004098
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DLEU2
Full Name:deleted in lymphocytic leukemia 2
Category:LncRNA
Species:Homo sapiens
Synonyms:ALT1|BCMSUN|DLB2|LEU2|LINC00022|MIR15AHG|NCRNA00022|RFP2|RFP2OS|TRIM13OS
Chromosome:13
Strand:-
Coordinate:
Start Site(bp):49982549End Site(bp):50125541
External Links:
Ensembl ID:ENSG00000231607
Ensembl Transcript ID:N/A
Entrez Gene:8847.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:36   
More Information
Causal Disease Number:28
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Stomach Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2154D009396
Disease Name:nephroblastomaWilms Tumor
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A kidney cancer that affects the kidneys and typically located_in children.A malignant kidney tumor, caused by the uncontrolled multiplication of renal stem (blastemal), stromal (STROMAL CELLS), and epithelial (EPITHELIAL CELLS) elements. However, not all three are present in every case. Several genes or chromosomal areas have been associated with Wilms tumor which is usually found in childhood as a firm lump in a child's side or ABDOMEN.
Alias:adult nephroblastomaWilms Tumor//Tumor, Wilms//Wilms' Tumor//Tumor, Wilms'//Wilm Tumor//Wilm's Tumor//Wilms Tumor 1//Nephroblastoma//Nephroblastomas//Bilateral Wilms Tumor//Tumor, Bilateral Wilms//Wilms Tumor, Bilateral

 

Disease Association Statistics

Total Associated ncRNA Number:36   
More Information
Causal ncRNA Number:34
Network:
Top Causal ncRNAs:
XIST  (Score: 0.985791)
XIST  (Score: 0.985791)
OSTM1-AS1  (Score: 0.731059)
SOX21-AS1  (Score: 0.731059)
circNCKAP1  (Score: 0.731059)
CRNDE  (Score: 0.731059)
H19  (Score: 0.731059)
HAGLROS  (Score: 0.731059)
hsa_circ_0093741  (Score: 0.731059)
DLEU2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:36209036
Disease Name:Wilms Tumor
Sample:Wilm's tumor tissues and in vitro cell lines
Dysfunction Pattern:Interaction(miR-539-3p/HOXB2 axis)
Validated Method:In Vivo Experiment//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//IHC//Transwell Assay
Description:DLEU2 and HOXB2 were significantly highly expressed in primary Wilm's tumor tissues and in vitro cell lines.MiR-539-3p was confirmed to be a target of DLEU2. DLEU2 silencing inhibited the malignant behaviors of Wilm's tumor cells by releasing miR-539-3p. In addition, HOXB2 was a target of miR-539-3p. Overexpression of HOXB2 partially restored the inhibitory effects of miR-539-3p on Wilm's tumor cell malignant behaviors.
Causality:Yes
Causal Description:Silencing of DLEU2 reduced the proliferation, migration and invasion of Wilm's tumor cells, and promoted cell apoptosis. Animal experiments also confirmed the anti-tumor effects of DLEU2 silencing in vivo.
Clinical-realted Application: