LncRNADisease3

Entry Detail

General Information

Database ID:	LDA0004124
Species:	Homo sapiens
Confidence Score:	0.731059
Contents:	>> ncRNA Information >> ncRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference
Causality:	Yes
Clinical Significance:	Unknown

ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:

DHRS4

Full Name:

dehydrogenase/reductase 4

Category:

LncRNA

Species:

Homo sapiens

Synonyms:

Chromosome:

Strand:

Coordinate:

Start Site(bp):

23953770

End Site(bp):

23969279

External Links:

Ensembl ID:	ENSG00000284807
Ensembl Transcript ID:	N/A
Entrez Gene:	10901.0
NONCODE ID:	N/A
RefSeq Accession:	N/A

ncRNA Association Statistics

Total Associated Disease Number:

2 More Information

Causal Disease Number:

Network:

Top Causal Diseases:

Endometriosis (Score: 0.731059)

More Information

Disease Information

	Disease Ontology	MeSH
Disease ID:	DOID:289	D004715
Disease Name:	endometriosis	Endometriosis
Category:	Disease Ontology	MeSH
Type:		Urogenital Diseases
Define:	A female reproductive system disease characterized by the growth of endometrial tissue outside the uterine body.	A condition in which functional endometrial tissue is present outside the UTERUS. It is often confined to the PELVIS involving the OVARY, the ligaments, cul-de-sac, and the uterovesical peritoneum.
Alias:		Endometriosis//Endometrioses//Endometrioma//Endometriomas

Disease Association Statistics

Total Associated ncRNA Number:

46 More Information

Causal ncRNA Number:

Network:

Top Causal ncRNAs:

MALAT1 (Score: 0.999893)

AFAP1-AS1 (Score: 0.999893)

MALAT1 (Score: 0.999893)

AFAP1-AS1 (Score: 0.999893)

HOTAIR (Score: 0.985791)

circATRNL1 (Score: 0.985791)

DHRS4 (Score: 0.731059)

CCDC144NL-AS1 (Score: 0.731059)

More Information

Evidence Support

Strong Evidence:	Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay
Weak Evidence:

Reference

[1] PubMed ID:	35414313
Disease Name:	Endometriosis
Sample:	EC-ESCs and tissues
Dysfunction Pattern:	Interaction(DHRS4-AS1/miR-139-5p/ARRDC3 axis )
Validated Method:	Western Blot//Transfection//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay
Description:	Compared with the EN group, DHRS4-AS1 levels were lower and miR-139-5p levels were higher in EC-ESCs and tissues obtained from patients with endometriosis. Functional assays validated that DHRS4-AS1 targets miR-139-5p, with ARRDC3 being a downstream target of miR-139-5p.Rescue experiments demonstrated that DHRS4-AS1 inhibited EC-ESC proliferation, migration, and invasion, but promoted apoptosis, by targeting miR-139-5p in endometriosis. cleaved-Caspase3 expression level and the cleaved-Caspase 3/Caspase 3 ratio increased, while the expression levels of MMP-9 decreased, after transfection with DHRS4-AS1 overexpression plasmids; however, the effects induced by DHRS4-AS1 overexpression could be partially reversed by co-transfection with the miR-139-5p mimic.
Causality:	Yes
Causal Description:	Rescue experiments demonstrated that DHRS4-AS1 inhibited EC-ESC proliferation, migration, and invasion, but promoted apoptosis, by targeting miR-139-5p in endometriosis. cleaved-Caspase3 expression level and the cleaved-Caspase 3/Caspase 3 ratio increased, while the expression levels of MMP-9 decreased, after transfection with DHRS4-AS1 overexpression plasmids; however, the effects induced by DHRS4-AS1 overexpression could be partially reversed by co-transfection with the miR-139-5p mimic.
Clinical-realted Application:

LncRNADisease v3.0

Entry Detail