Entry Detail

General Information

Database ID: LDA0004126
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DGUOK-AS1
Full Name:DGUOK antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:2
Strand:-
Coordinate:
Start Site(bp):73957967End Site(bp):73981439
External Links:
Ensembl ID:ENSG00000237883
Ensembl Transcript ID:N/A
Entrez Gene:100874048.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 0.731059)
cervical squamous cell carcinoma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
cervical squamous cell carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3744
Disease Name:cervical squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A cervix carcinoma that has_material_basis_in squamous cells of the cervix.
Alias:squamous cell carcinoma of cervix//squamous cell carcinoma of the Cervix Uteri

 

Disease Association Statistics

Total Associated ncRNA Number:52   
More Information
Causal ncRNA Number:50
Network:
Top Causal ncRNAs:
MCM3AP-AS1  (Score: 0.985791)
MCM3AP-AS1  (Score: 0.985791)
MAGI2-AS3  (Score: 0.985791)
MAGI2-AS3  (Score: 0.985791)
SLC16A1-AS1  (Score: 0.731059)
GATA6-AS  (Score: 0.731059)
BLACAT1  (Score: 0.731059)
CASC9-1  (Score: 0.731059)
DGUOK-AS1  (Score: 0.731059)
MACC1-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//CCK8//qRT-PCR//RIP//migration assay//Luciferase Report Assay//BrdU
Weak Evidence:

 

Reference

[1] PubMed ID:34808501
Disease Name:cervical squamous cell carcinoma
Sample:CESC tissues and cells
Dysfunction Pattern:Interaction(miR-499a-5p/ SPRR1B )
Validated Method:Western Blot//Transfection//CCK8//qRT-PCR//RIP//migration assay//Luciferase Report Assay//BrdU
Description:DGUOK-AS1 and SPRR1B expressions were obviously elevated, whereas the expression of miR-499a-5p was reduced in both CESC tissues and cells. Notably, DGUOK-AS1 inhibited miR-499a-5p to release SPRR1B, which significantly accelerated the development of CESC.
Causality:Yes
Causal Description:Silencing of DGUOK-AS1 attenuated cell growth and boosted apoptosis of CESC cells. Notably, DGUOK-AS1 inhibited miR-499a-5p to release SPRR1B, which significantly accelerated the development of CESC.
Clinical-realted Application: