Entry Detail

General Information

Database ID: LDA0004142
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DLEU1
Full Name:deleted in lymphocytic leukemia 1
Category:LncRNA
Species:Homo sapiens
Synonyms:BCMS|BCMS1|DLB1|DLEU2|LEU1|LEU2|LINC00021|NCRNA00021|XTP6
Chromosome:13
Strand:+
Coordinate:
Start Site(bp):50082169End Site(bp):50528643
External Links:
Ensembl ID:ENSG00000176124
Ensembl Transcript ID:N/A
Entrez Gene:10301.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:30   
More Information
Causal Disease Number:28
Network:
Top Causal Diseases:
Glioblastoma  (Score: 0.999893)
Endometrial Neoplasms  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Glioblastoma  (Score: 0.999893)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.999893)
Endometrial Neoplasms  (Score: 0.999893)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:C567838
Disease Name:Premature Ovarian Failure 7
Category:MeSH
Type:Urogenital Diseases
Define:aka POF7
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
DLEU1  (Score: 0.731059)
DLEU1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Transfection//RNA Pull-Down//Cell Apoptosis Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34740384
Disease Name:Premature Ovarian Failure 7
Sample:POF and control ovary tissues
Dysfunction Pattern:Interaction( MiR-146b-5p)
Validated Method:qRT-PCR//Transfection//RNA Pull-Down//Cell Apoptosis Assay
Description:Increased DLEU1 expression and decreased miR-146b-5p expression were observed in POF.DLEU1 directly interacted with MiR-146b-5p and was expressed in both nuclear and cytoplasm samples of KGN cells.
Causality:Yes
Causal Description:In KGN cells, DLEU1 and miR-146b-5p failed to regulate the expression of each other. However, DLEU1 promoted cell apoptosis and reduced the inhibitory effects of miR-146b-5p on cell apoptosis.
Clinical-realted Application: