Entry Detail

General Information

Database ID: LDA0004151
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:DIRC1
Full Name:disrupted in renal carcinoma 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:2
Strand:-
Coordinate:
Start Site(bp):188733738End Site(bp):188790123
External Links:
Ensembl ID:ENSG00000174325
Ensembl Transcript ID:N/A
Entrez Gene:116093.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Stomach Neoplasms  (Score: 0.731059)
gastric adenocarcinoma  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
gastric adenocarcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3717
Disease Name:gastric adenocarcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A stomach carcinoma that derives_from epithelial cells of glandular origin.
Alias:adenocarcinoma of stomach//stomach adenocarcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:40   
More Information
Causal ncRNA Number:28
Network:
Top Causal ncRNAs:
MALAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
PMS2P2  (Score: 0.731059)
ITGB1-DT  (Score: 0.731059)
FOXCUT  (Score: 0.731059)
HAND2-AS1  (Score: 0.731059)
DIRC1  (Score: 0.731059)
RP1-163G9.1  (Score: 0.731059)
TM4SF1-AS1  (Score: 0.731059)
TRPM2-AS  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:36401393
Disease Name:gastric adenocarcinoma
Sample: macrophages, dendritic cells, and Th1 cells
Dysfunction Pattern:Regulation
Validated Method:qRT-PCR//RNA-seq//Bioinformatics Analysis
Description: Increased DIRC1 expression in STAD was associated with T stage (P = .004), race (P = .045), histologic grade (P = .029) and anatomic neoplasm subdivision (P = .034).
Causality:Yes
Causal Description:DIRC1 is related to epidermis, collagen-containing extracellular matrix, receptor-ligand activity, protein digestion and absorption, etc.
Clinical-realted Application: Increased DIRC1 expression in STAD was associated with T stage (P = .004), race (P = .045), histologic grade (P = .029) and anatomic neoplasm subdivision (P = .034).