LncRNADisease3

Entry Detail

General Information

Database ID:	LDA0004176
Species:	Homo sapiens
Confidence Score:	0.985791
Contents:	>> ncRNA Information >> ncRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference
Causality:	Yes
Clinical Significance:	Yes

ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:

AGAP2-AS1

Full Name:

AGAP2 antisense RNA 1

Category:

LncRNA

Species:

Homo sapiens

Synonyms:

PUNISHER

Chromosome:

Strand:

Coordinate:

Start Site(bp):

57726240

End Site(bp):

57728356

External Links:

Ensembl ID:	ENSG00000255737
Ensembl Transcript ID:	N/A
Entrez Gene:	100130776.0
NONCODE ID:	N/A
RefSeq Accession:	N/A

ncRNA Association Statistics

Total Associated Disease Number:

38 More Information

Causal Disease Number:

Network:

Top Causal Diseases:

Colorectal Neoplasms (Score: 0.999893)

Glioma (Score: 0.985791)

Cholangiocarcinoma (Score: 0.985791)

Prostatic Neoplasms (Score: 0.985791)

Thyroid Cancer, Papillary (Score: 0.985791)

Colonic Neoplasms (Score: 0.985791)

Glioma (Score: 0.985791)

Colonic Neoplasms (Score: 0.985791)

Prostatic Neoplasms (Score: 0.985791)

More Information

Disease Information

	Disease Ontology	MeSH
Disease ID:		D000077273
Disease Name:		Thyroid Cancer, Papillary
Category:		MeSH
Type:		Neoplasms
Define:		An ADENOCARCINOMA that originates from follicular cells of the THYROID GLAND and accounts for the majority of THYROID CANCER cases. Cells exhibit enlarged, oval, or elongated morphologies with clear, round, nuclei. Fusions of RET, NTRK1, TPM3, and PCM1 genes are associated with this cancer.
Alias:		Thyroid Cancer, Papillary//Cancer, Papillary Thyroid//Cancers, Papillary Thyroid//Papillary Thyroid Cancer//Papillary Thyroid Cancers//Thyroid Cancers, Papillary//Thyroid Carcinoma, Papillary//Carcinoma, Papillary Thyroid//Carcinomas, Papillary Thyroid//Papillary Thyroid Carcinomas//Thyroid Carcinomas, Papillary//Papillary Carcinoma Of Thyroid//Papillary Thyroid Carcinoma//Familial Nonmedullary Thyroid Cancer//Nonmedullary Thyroid Carcinoma//Carcinoma, Nonmedullary Thyroid//Carcinomas, Nonmedullary Thyroid//Nonmedullary Thyroid Carcinomas//Thyroid Carcinoma, Nonmedullary//Thyroid Carcinomas, Nonmedullary

Disease Association Statistics

Total Associated ncRNA Number:

340 More Information

Causal ncRNA Number:

280

Network:

Top Causal ncRNAs:

UCA1 (Score: 0.999893)

HOTAIR (Score: 0.999893)

LINC00460 (Score: 0.999893)

HOTAIR (Score: 0.999893)

LINC00460 (Score: 0.999893)

BICDL3P (Score: 0.999358)

hsa_circ_0000644 (Score: 0.985791)

circRAPGEF5 (Score: 0.985791)

More Information

Evidence Support

Strong Evidence:	Western Blot//Wound Healing Assay//Migration Assay//CCK8//qRT-PCR//FISH//Luciferase Report Assay//Invasion Assay//Transwell Assay
Weak Evidence:

Reference

[1] PubMed ID:	32960785
Disease Name:	Thyroid Cancer, Papillary
Sample:	PTC tissues
Dysfunction Pattern:	interaction[binding to miRNA-425-5p]
Validated Method:	Western Blot//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Transwell Assay
Description:	We found that AGAP2-AS1 expression was significantly higher in human PTC tissues than adjacent noncancerous tissues (n=110; p<0.01) and correlated with lymph node metastasis (p=0.01) and tumor-node-metastasis stage (p=0.006). These results demonstrate that AGAP2-AS1 expression is significantly elevated in PTC tissues and that, by binding to miRNA-425-5p, it upregulates the MMP2 expression, thereby increasing the invasiveness and migration capacity of PTC cells.
Causality:	Yes
Causal Description:	AGAP2-AS1 downregulation decreased migration and invasion by PTC cells, and reduced expression of matrix metalloproteinase-2 (MMP2).
Clinical-realted Application:	We found that AGAP2-AS1 expression was significantly higher in human PTC tissues than adjacent noncancerous tissues (n=110; p<0.01) and correlated with lymph node metastasis (p=0.01) and tumor-node-metastasis stage (p=0.006).

[2] PubMed ID:	33604734
Disease Name:	Thyroid Cancer, Papillary
Sample:	PTC tissues and cell lines
Dysfunction Pattern:	Interaction(MiR-628-5p)
Validated Method:	Western Blot//Migration Assay//CCK8//qRT-PCR//Luciferase Report Assay//Invasion Assay
Description:	Our results showed that AGAP2-AS1 was significantly upregulated in PTC tissues. MiR-628-5p was found to act as a target miRNA of AGAP2-AS1 in PTC. The expression level of miR-628-5p in PTC tissues was negatively associated with that of AGAP2-AS1.
Causality:	Yes
Causal Description:	Knockdown of AGAP2-AS1 inhibited the proliferation, migration and invasion of PTC cells. In vivo experiment showed that AGAP2-AS1 knockdown inhibited the tumorigenesis of PTC.
Clinical-realted Application:

LncRNADisease v3.0

Entry Detail