Entry Detail

General Information

Database ID: LDA0004184
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:AGAP2-AS1
Full Name:AGAP2 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:PUNISHER
Chromosome:12
Strand:+
Coordinate:
Start Site(bp):57726240End Site(bp):57728356
External Links:
Ensembl ID:ENSG00000255737
Ensembl Transcript ID:N/A
Entrez Gene:100130776.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:38   
More Information
Causal Disease Number:34
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
Glioma  (Score: 0.985791)
Cholangiocarcinoma  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Thyroid Cancer, Papillary  (Score: 0.985791)
Colonic Neoplasms  (Score: 0.985791)
Glioma  (Score: 0.985791)
Colonic Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:8893D011565
Disease Name:psoriasisPsoriasis
Category:Disease OntologyMeSH
Type:Skin and Connective Tissue Diseases
Define:A skin disease that is characterized by patches of thick red skin and silvery scales.A common genetically determined, chronic, inflammatory skin disease characterized by rounded erythematous, dry, scaling patches. The lesions have a predilection for nails, scalp, genitalia, extensor surfaces, and the lumbosacral region. Accelerated epidermopoiesis is considered to be the fundamental pathologic feature in psoriasis.
Alias:Psoriasis//Psoriases//Pustulosis of Palms and Soles//Pustulosis Palmaris et Plantaris//Palmoplantaris Pustulosis//Pustular Psoriasis of Palms and Soles

 

Disease Association Statistics

Total Associated ncRNA Number:28   
More Information
Causal ncRNA Number:18
Network:
Top Causal ncRNAs:
HOTAIR  (Score: 0.731059)
NORAD  (Score: 0.731059)
Meg3  (Score: 0.731059)
SPRR2C  (Score: 0.731059)
circVAPA  (Score: 0.731059)
circEIF5  (Score: 0.731059)
XIST  (Score: 0.731059)
AGAP2-AS1  (Score: 0.731059)
chr2:206992521|206994966  (Score: 0.731059)
HOTAIR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//MeRIP//Transfection//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34930676
Disease Name:Psoriasis
Sample:skin tissue of psoriasis patients
Dysfunction Pattern:Interaction(miR-424-5p/AKT3 axis)
Validated Method:Western Blot//Transfection//MeRIP//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay
Description:We found that AGAP2-AS1 level was upregulated in the skin tissue of psoriasis patients than that of healthy controls and AGAP2-AS1 could promote proliferation and inhibit apoptosis of keratinocytes. Methyltransferase like 3(METTL3)-mediated m6A modification suppressed the expression of AGAP2-AS1 via YTHDF2-dependent AGAP2-AS1 stability. Thus, downregulation of METTL3 resulted in the upregulation of AGAP2-AS1 in psoriasis. AGAP2-AS1 functioned as a competitive endogenous RNA by sponging miR-424-5p to upregulate AKT3, activate AKT/mTOR pathway, as well as promote cell proliferation in keratinocytes.
Causality:Yes
Causal Description:We found that AGAP2-AS1 level was upregulated in the skin tissue of psoriasis patients than that of healthy controls and AGAP2-AS1 could promote proliferation and inhibit apoptosis of keratinocytes.
Clinical-realted Application: