Entry Detail

General Information

Database ID: LDA0004196
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ADAMTS9-AS2
Full Name:ADAMTS9 antisense RNA 2
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:3
Strand:+
Coordinate:
Start Site(bp):64684870End Site(bp):65011468
External Links:
Ensembl ID:ENSG00000241684
Ensembl Transcript ID:N/A
Entrez Gene:100507098.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:28   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.985791)
Esophageal Neoplasms  (Score: 0.985791)
Esophageal Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Ischemic Stroke  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Oral Submucous Fibrosis  (Score: 0.731059)
Liver Neoplasms  (Score: 0.731059)
tongue squamous cell carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D003528
Disease Name:Carcinoma, Adenoid Cystic
Category:MeSH
Type:Neoplasms
Define:Carcinoma characterized by bands or cylinders of hyalinized or mucinous stroma separating or surrounded by nests or cords of small epithelial cells. When the cylinders occur within masses of epithelial cells, they give the tissue a perforated, sievelike, or cribriform appearance. Such tumors occur in the mammary glands, the mucous glands of the upper and lower respiratory tract, and the salivary glands. They are malignant but slow-growing, and tend to spread locally via the nerves. (Dorland, 27th ed)
Alias:Carcinoma, Adenoid Cystic//Adenoid Cystic Carcinoma//Adenoid Cystic Carcinomas//Carcinomas, Adenoid Cystic//Cystic Carcinoma, Adenoid//Cystic Carcinomas, Adenoid//Adenocystic Carcinoma//Adenocystic Carcinomas//Carcinoma, Adenocystic//Carcinomas, Adenocystic//Cylindroma//Cylindromas

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:8
Network:
Top Causal ncRNAs:
ADAMTS9-AS2  (Score: 0.731059)
MRPL23-AS1  (Score: 0.731059)
hsa_circ_001982  (Score: 0.731059)
hsa_circ_0011946  (Score: 0.731059)
ADAMTS9-AS2  (Score: 0.731059)
MRPL23-AS1  (Score: 0.731059)
hsa_circ_001982  (Score: 0.731059)
hsa_circ_0011946  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//ISH//qRT-PCR//Luciferase Report Assay//ChIP
Weak Evidence:

 

Reference

[1] PubMed ID:30217729
Disease Name:Carcinoma, Adenoid Cystic
Sample:cells
Dysfunction Pattern:Regulation[PI3K/Akt and MEK/Erk Signaling]
Validated Method:RNA Pull-Down//Western Blot//ISH//qRT-PCR//Luciferase Report Assay//ChIP
Description:In our study, we found that ADAM metallopeptidase with thrombospondin type 1 motif, 9 (ADAMTS9) antisense RNA 2 (ADAMTS9-AS2) was significantly upregulated in SACC patients with metastasis and SACC-lung metastasis (LM) cells.Overexpression of ADAMTS9-AS2 competitively bound to miR-143-3p that inhibited ITGA6 from miRNA-mediated degradation, and thus it activated the activity of PI3K/Akt and MEK/Erk signaling and facilitated SACC metastasis.
Causality:Yes
Causal Description:Knockdown of ADAMTS9-AS2 significantly inhibited migration and invasion of SACC cells in vitro and distant lung metastasis in vivo.
Clinical-realted Application:Moreover, ADAMTS9-AS2 expression was closely associated with the prognosis and distant metastasis in SACC patients.