Entry Detail

General Information

Database ID: LDA0004197
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ADAMTS9-AS2
Full Name:ADAMTS9 antisense RNA 2
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:3
Strand:+
Coordinate:
Start Site(bp):64684870End Site(bp):65011468
External Links:
Ensembl ID:ENSG00000241684
Ensembl Transcript ID:N/A
Entrez Gene:100507098.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:28   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.985791)
Esophageal Neoplasms  (Score: 0.985791)
Esophageal Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Ischemic Stroke  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Oral Submucous Fibrosis  (Score: 0.731059)
Liver Neoplasms  (Score: 0.731059)
tongue squamous cell carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050865
Disease Name:tongue squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A head and neck squamous cell carcinoma that is located_in the tongue.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:140   
More Information
Causal ncRNA Number:70
Network:
Top Causal ncRNAs:
hsa_circ_0001742  (Score: 1)
hsa_circ_0001742  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
CASC15  (Score: 0.985791)
hsa_circ_0002162  (Score: 0.985791)
CASC15  (Score: 0.985791)
hsa_circ_0000231  (Score: 0.985791)
hsa_circ_0002162  (Score: 0.985791)
hsa_circ_0000231  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:Western Blot//ISH//qRT-PCR//RIP//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30970517
Disease Name:tongue squamous cell carcinoma
Sample:TSCC tissues
Dysfunction Pattern:Regulation[miR-600/EZH2 axis]
Validated Method:Western Blot//ISH//qRT-PCR//RIP//Luciferase Report Assay
Description:Our results indicate that the lncRNA ADAMTS9-AS2 is most significantly upregulated in TSCC tissues from patients with lymph node metastasis and is closely associated with poor prognosis. In summary, our results demonstrate an explicit oncogenic role of ADAMTS9-AS2 in TSCC tumorigenesis via competition with miR-600, suggesting a new regulatory mechanism of ADAMTS9-AS2 and providing a potential therapeutic target for TSCC patients.
Causality:Yes
Causal Description: Furthermore, ADAMTS9-AS2 knockdown in TSCC cells leads to a inhibition of cell migration and invasion and reverses TGF-β1 induced EMT. ADAMTS9-AS2 knockdown also inhibits TSCC cell growth in vitro and in vivo.
Clinical-realted Application: