Entry Detail

General Information

Database ID: LDA0004199
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ADAMTS9-AS2
Full Name:ADAMTS9 antisense RNA 2
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:3
Strand:+
Coordinate:
Start Site(bp):64684870End Site(bp):65011468
External Links:
Ensembl ID:ENSG00000241684
Ensembl Transcript ID:N/A
Entrez Gene:100507098.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:28   
More Information
Causal Disease Number:20
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.985791)
Esophageal Neoplasms  (Score: 0.985791)
Esophageal Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Ischemic Stroke  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Oral Submucous Fibrosis  (Score: 0.731059)
Liver Neoplasms  (Score: 0.731059)
tongue squamous cell carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5773D009914
Disease Name:oral submucous fibrosisOral Submucous Fibrosis
Category:Disease OntologyMeSH
Type:Stomatognathic Diseases
Define:A mouth disease that is characterized by juxta-epithelial inflammatory reaction and progressive fibrosis of the submucosal tissues.Irreversible FIBROSIS of the submucosal tissue of the MOUTH.
Alias:Oral cavity Submucous Fibrosis//Oral submucosal fibrosis//Oral submucosal fibrosis, including of tongueOral Submucous Fibrosis//Fibroses, Oral Submucous//Fibrosis, Oral Submucous//Oral Submucous Fibroses//Submucous Fibroses, Oral//Submucous Fibrosis, Oral

 

Disease Association Statistics

Total Associated ncRNA Number:4   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
LINC00974  (Score: 0.731059)
ADAMTS9-AS2  (Score: 0.731059)
LINC00974  (Score: 0.731059)
ADAMTS9-AS2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33345447
Disease Name:Oral Submucous Fibrosis
Sample:OSCC tissues
Dysfunction Pattern:regulation[AKT signalling pathway]
Validated Method:Western Blot//qRT-PCR//Cell Proliferation Assay//Colony Formation Assay//Transwell Assay
Description:lncRNA ADAMTS9-AS2 is down-regulated in OSCC tissues compared with OSF and normal mucous tissues. Through profiling miRNA expression profile regulated by exosomal ADAMTS9-AS2, significantly enriched pathways include metabolic pathway, PI3K-Akt signalling pathway and pathways in cancer, indicating that exosomal ADAMTS9-AS2 exerts its functions through interacting with miRNAs during OSF progression.
Causality:Yes
Causal Description: Functional studies reveal that exosomal ADAMTS9-AS2 suppresses OSCC cell growth, migration and invasion in vitro.
Clinical-realted Application:Low ADAMTS9-AS2 expression is associated with poor overall survival.