Entry Detail

General Information

Database ID: LDA0004214
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:AFAP1-AS1
Full Name:AFAP1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:AFAP1-AS|AFAP1AS
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):7754090End Site(bp):7778928
External Links:
Ensembl ID:ENSG00000272620
Ensembl Transcript ID:N/A
Entrez Gene:84740.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:60   
More Information
Causal Disease Number:58
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Prostatic Neoplasms  (Score: 0.999893)
Endometriosis  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Endometriosis  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:2600
Disease Name:laryngeal carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A larynx cancer that has_material_basis_in epithelial cells.
Alias:cancer of larynx//carcinoma of larynx

 

Disease Association Statistics

Total Associated ncRNA Number:22   
More Information
Causal ncRNA Number:18
Network:
Top Causal ncRNAs:
FOXD2-AS1  (Score: 0.731059)
WTAPP1  (Score: 0.731059)
SNHG3  (Score: 0.731059)
circABCB10  (Score: 0.731059)
CASC9  (Score: 0.731059)
AFAP1-AS1  (Score: 0.731059)
LINC01303  (Score: 0.731059)
LINC00886  (Score: 0.731059)
MALAT1  (Score: 0.731059)
FOXD2-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35968243
Disease Name:laryngeal carcinoma
Sample:LC patients
Dysfunction Pattern:Expression(highly expressed)
Validated Method:Transfection//Wound Healing Assay//Flow Cytometry//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay
Description:Herein, a remarkable elevation of lncRNA AFAP1-AS1 was observed in LC patients.
Causality:Yes
Causal Description:Moreover, lncRNA AFAP1-AS1 silencing was revealed to repress TU212 malignant phenotypes.
Clinical-realted Application:And higher lncRNA AFAP1-AS1 level was correlated to worse clinical pathological characteristics.