Entry Detail

General Information

Database ID: LDA0004216
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:AFAP1-AS1
Full Name:AFAP1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:AFAP1-AS|AFAP1AS
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):7754090End Site(bp):7778928
External Links:
Ensembl ID:ENSG00000272620
Ensembl Transcript ID:N/A
Entrez Gene:84740.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:60   
More Information
Causal Disease Number:58
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Carcinoma, Non-Small-Cell Lung  (Score: 1)
Breast Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Stomach Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Prostatic Neoplasms  (Score: 0.999893)
Endometriosis  (Score: 0.999893)
Prostatic Neoplasms  (Score: 0.999893)
Endometriosis  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4948
Disease Name:gallbladder carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A gallbladder cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
Alias:cancer of the gallbladder//carcinoma gallbladder//carcinoma of gallbladder

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:16
Network:
Top Causal ncRNAs:
lnc-DILC  (Score: 0.731059)
AFAP1-AS1  (Score: 0.731059)
hsa_circ_0008234  (Score: 0.731059)
SNHG6  (Score: 0.731059)
TTN-AS1  (Score: 0.731059)
TMPO-AS1  (Score: 0.731059)
MYLK-AS1  (Score: 0.731059)
lnc-DILC  (Score: 0.731059)
AFAP1-AS1  (Score: 0.731059)
hsa_circ_0008234  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35404727
Disease Name:gallbladder carcinoma
Sample:GBC cell
Dysfunction Pattern:Interaction(AFAP1-AS1/hsa-miR-15a-5p/bcl-2 axis)
Validated Method:Western Blot//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay
Description:In SGC-996 and NOZ cells, AFAP1-AS1 was significantly expressed and hsa-miR-15a-5p was modestly expressed. In addition, AFAP1-AS1 bound hsa-miR-15a-5p and hsa-miR-15a-5p targeted bcl-2. Increased bcl-2 expression was observed in the GBC cells. AFAP1-AS1 may regulate GBC cell proliferation and apoptosis via has-miR-15a-5p to mediate bcl-2 expression.
Causality:Yes
Causal Description:Transfection of the hsa-miR-15a-5p inhibitor elevated proliferation of SGC-996 and NOZ cells and decreased apoptosis, whereas transfection of si-AFAP1-AS1 reduced the proliferation rate and increased apoptosis.
Clinical-realted Application: