Entry Detail

General Information

Database ID: LDA0004238
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ANAPC7
Full Name:anaphase promoting complex subunit 7
Category:LncRNA
Species:Homo sapiens
Synonyms:APC7|FERBON
Chromosome:12
Strand:-
Coordinate:
Start Site(bp):110372900End Site(bp):110403708
External Links:
Ensembl ID:ENSG00000196510
Ensembl Transcript ID:N/A
Entrez Gene:51434.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Pancreatic Neoplasms  (Score: 0.731059)
Pancreatic Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1793D010190
Disease Name:pancreatic cancerPancreatic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An endocrine gland cancer located_in the pancreas.Tumors or cancer of the PANCREAS. Depending on the types of ISLET CELLS present in the tumors, various hormones can be secreted: GLUCAGON from PANCREATIC ALPHA CELLS; INSULIN from PANCREATIC BETA CELLS; and SOMATOSTATIN from the SOMATOSTATIN-SECRETING CELLS. Most are malignant except the insulin-producing tumors (INSULINOMA).
Alias:Ca body of pancreas//Ca head of pancreas//Ca tail of pancreas//malignant neoplasm of body of pancreas//malignant neoplasm of head of pancreas//malignant neoplasm of tail of pancreas//pancreas neoplasm//pancreatic neoplasm//pancreatic tumorPancreatic Neoplasms//Neoplasm, Pancreatic//Pancreatic Neoplasm//Pancreas Neoplasms//Neoplasm, Pancreas//Neoplasms, Pancreas//Pancreas Neoplasm//Neoplasms, Pancreatic//Cancer of Pancreas//Pancreas Cancers//Pancreas Cancer//Cancer, Pancreas//Cancers, Pancreas//Pancreatic Cancer//Cancer, Pancreatic//Cancers, Pancreatic//Pancreatic Cancers//Cancer of the Pancreas

 

Disease Association Statistics

Total Associated ncRNA Number:322   
More Information
Causal ncRNA Number:280
Network:
Top Causal ncRNAs:
DANCR  (Score: 1)
XIST  (Score: 1)
LINC00261  (Score: 1)
DANCR  (Score: 1)
XIST  (Score: 1)
LINC00261  (Score: 1)
CASC2  (Score: 0.999893)
CASC2  (Score: 0.999893)
LINC00460  (Score: 0.999893)
LINC00460  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Luciferase Report Assay//RIP
Weak Evidence:

 

Reference

[1] PubMed ID:35176309
Disease Name:Pancreatic Neoplasms
Sample:human pancreatic cancer cells, 3-dimensional spheroids and organoids, mouse models, and clinical specimens
Dysfunction Pattern:Interaction(CREB-miR-373-PHLPP2 axis)
Validated Method:In Vivo Experiment//RNA Pull-Down//Luciferase Report Assay//RIP
Description: We identified circANAPC7 as a sponge for miR-373, which inhibited tumor growth and muscle wasting in vitro and in vivo. This study identified circANAPC7 as a novel tumor suppressor, which functions through the CREB-miR-373-PHLPP2 axis, leading to AKT dephosphorylation, and cyclin D1 and transforming growth factor-β down-regulation to suppress tumor growth and muscle wasting in pancreatic cancer.
Causality:Yes
Causal Description: We identified circANAPC7 as a sponge for miR-373, which inhibited tumor growth and muscle wasting in vitro and in vivo.
Clinical-realted Application: