Entry Detail

General Information

Database ID: LDA0004247
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ARHGAP10
Full Name:Rho GTPase activating protein 10
Category:LncRNA
Species:Homo sapiens
Synonyms:GRAF2|PS-GAP|PSGAP
Chromosome:4
Strand:+
Coordinate:
Start Site(bp):147732088End Site(bp):148072776
External Links:
Ensembl ID:ENSG00000071205
Ensembl Transcript ID:N/A
Entrez Gene:79658.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3908D002289
Disease Name:lung non-small cell carcinomaCarcinoma, Non-Small-Cell Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Alias:NSCLC//Non-small cell lung cancer//non-small cell lung carcinomaCarcinoma, Non-Small-Cell Lung//Carcinoma, Non Small Cell Lung//Carcinomas, Non-Small-Cell Lung//Lung Carcinoma, Non-Small-Cell//Lung Carcinomas, Non-Small-Cell//Non-Small-Cell Lung Carcinomas//Non-Small-Cell Lung Carcinoma//Non Small Cell Lung Carcinoma//Carcinoma, Non-Small Cell Lung//Non-Small Cell Lung Carcinoma//Non-Small Cell Lung Cancer//Nonsmall Cell Lung Cancer

 

Disease Association Statistics

Total Associated ncRNA Number:1090   
More Information
Causal ncRNA Number:936
Network:
Top Causal ncRNAs:
AFAP1-AS1  (Score: 1)
FEZF1-AS1  (Score: 1)
BCYRN1  (Score: 1)
GAS5  (Score: 1)
MALAT1  (Score: 1)
MAGI2-AS3  (Score: 1)
AWPPH  (Score: 1)
DANCR  (Score: 1)
hsa_circ_0007385  (Score: 1)
hsa_circ_0074027  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//FISH//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31561126
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:NSCLC tissues ,cell lines
Dysfunction Pattern:Regulation[miR-150-5p/GLUT-1 Axis ]
Validated Method:CCK8//FISH//qRT-PCR//Luciferase Report Assay//RNA-seq//Transwell Assay
Description:Thus, the present study aims at investigating the role of circARHGAP10 in NSCLC progression, which has been observed to be significantly upregulated in both NSCLC tissues and cell lines with profile analysis.Silencing circARHGAP10 also suppressed proliferation and metastasis by targeting the miR-150-5p/GLUT1 axis in NSCLC, which was confirmed with a luciferase reporter assay. Overexpression of GLUT1 or downregulation miR-150-5p will recover NSCLC cell proliferation and metastasis after a knockdown of circARHGAP10.
Causality:Yes
Causal Description:Silencing circARHGAP10 also suppressed proliferation and metastasis by targeting the miR-150-5p/GLUT1 axis in NSCLC, which was confirmed with a luciferase reporter assay. Overexpression of GLUT1 or downregulation miR-150-5p will recover NSCLC cell proliferation and metastasis after a knockdown of circARHGAP10.
Clinical-realted Application:A higher expression of circARHGAP10 also leads to a poor prognosis in NSCLC patients with fluorescence in situ hybridization (FISH).

[2] PubMed ID:32783691
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:NSCLC tissues, cells, and serum-derived exosomes
Dysfunction Pattern:Interaction( miR-638/FAM83F Axis)
Validated Method:qRT-PCR//MTT//Luciferase Report Assay//Western Blot
Description:circARHGAP10 was upregulated in NSCLC tissues, cells, and serum-derived exosomes.Serum-derived exosomes boosted the expression of circARHGAP10 in NSCLC cells. Also, miR-638 acted as a target of circARHGAP10, miR-638 overexpression overturned circARHGAP10 upregulation-mediated acceleration of proliferation, migration, invasion, and glycolysis of NSCLC cells. Besides, miR-638 targeted FAM83F and FAM83F overexpression abolished miR-638 enhancement-mediated proliferation, migration, invasion, and glycolysis of NSCLC cells.
Causality:Yes
Causal Description:circARHGAP10 depletion repressed proliferation, migration, invasion, and glycolysis of NSCLC cells in vitro, and curbed tumor growth in vivo.
Clinical-realted Application: