Entry Detail

General Information

Database ID: LDA0004254
Species: Homo sapiens
Confidence Score: 0.999893
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ARAP1-AS1
Full Name:ARAP1 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:-
Chromosome:N/A
Strand:N/A
Coordinate:
Start Site(bp):0End Site(bp):0
External Links:
Ensembl ID:ENSG00000256007
Ensembl Transcript ID:N/A
Entrez Gene:100874075.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Uterine Cervical Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.999893)
Urinary Bladder Neoplasms  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Breast Neoplasms  (Score: 0.731059)
Lung Neoplasms  (Score: 0.731059)
Colorectal Neoplasms  (Score: 0.731059)
Ovarian Neoplasms  (Score: 0.731059)
Thyroid Neoplasms  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4362D002583
Disease Name:cervical cancerUterine Cervical Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A female reproductive organ cancer that is located_in the cervix.Tumors or cancer of the UTERINE CERVIX.
Alias:cervical neoplasm//cervix cancer//cervix uteri cancer//neoplasm of uterine cervix//tumor of the Cervix Uteri//uterine cervical neoplasmUterine Cervical Neoplasms//Cervical Neoplasm, Uterine//Neoplasm, Uterine Cervical//Uterine Cervical Neoplasm//Neoplasms, Cervical//Cervical Neoplasms//Cervical Neoplasm//Neoplasms, Cervix//Cervix Neoplasm//Neoplasm, Cervix//Cervix Neoplasms//Cancer of the Uterine Cervix//Cancer of the Cervix//Cervical Cancer//Cancer, Cervical//Cervical Cancers//Uterine Cervical Cancer//Cancer, Uterine Cervical//Cervical Cancer, Uterine//Uterine Cervical Cancers//Cancer of Cervix//Cervix Cancer//Cancer, Cervix

 

Disease Association Statistics

Total Associated ncRNA Number:15334   
More Information
Causal ncRNA Number:532
Network:
Top Causal ncRNAs:
UCA1  (Score: 1)
CRNDE  (Score: 1)
WT1-AS  (Score: 1)
PVT1  (Score: 1)
LINC00511  (Score: 1)
DARS1-AS1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
OIP5-AS1  (Score: 1)
CRNDE  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//IHC//ChIP//Western Blot//Transfection//CCK8//qRT-PCR//RIP//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32985327
Disease Name:Uterine Cervical Neoplasms
Sample:cervical cancer cells
Dysfunction Pattern:regulation[ARAP1-AS1/EZH2/DUSP5 axis ]
Validated Method:CCK8//qRT-PCR//Colony Formation Assay//EdU Staining//Transwell Assay
Description: In the current research, ARAP1-AS1 was discovered to exhibit a high level in cervical cancer cells. Finally, rescue assays certified the oncogenic function of ARAP1-AS1/EZH2/DUSP5 axis in cervical cancer.
Causality:Yes
Causal Description:Besides, the knockdown of ARAP1-AS1 repressed cell proliferative and migratory capacities in cervical cancer, as detected by loss-of-function assays including CCK-8, EdU, colony formation, and transwell assays.
Clinical-realted Application:

[2] PubMed ID:31953923
Disease Name:Uterine Cervical Neoplasms
Sample:cervical cancer (CC) tissues, cell lines and serum
Dysfunction Pattern:Expression[highly expressed]
Validated Method:RNA Pull-Down//ChIP//Western Blot//CCK8//qRT-PCR//RIP//Luciferase Report Assay//Transwell Assay
Description:Here, we focused on an oncogenic lncRNA, ARAP1 antisense RNA 1 (ARAP1-AS1), which was notably upregulated in cervical cancer (CC) tissues, cell lines and serum.
Causality:Yes
Causal Description:In vitro and in vivo assays showed that knockdown of ARAP1-AS1 inhibited, while overexpression of ARAP1-AS1 promoted CC cell growth and dissemination.
Clinical-realted Application: High ARAP1-AS1 expression was closely associated with larger tumor size, advanced FIGO stage as well as lymph node metastasis.

[3] PubMed ID:33965958
Disease Name:Uterine Cervical Neoplasms
Sample:CC samples
Dysfunction Pattern:Interaction(miR-149-3p and POU2F2)
Validated Method:In Vivo Experiment//IHC//Western Blot//Transfection//CCK8//qRT-PCR//Flow Cytometry//RIP//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description: The expression of ARAP1-AS1 was enhanced in CC samples, while miR-149-3p was markedly suppressed. ARAP1-AS1 downregulated miR-149-3p via sponging it. ARAP1-AS1 and miR-149-3p exhibited a negative correlation in CC samples. On the other hand, ARAP1-AS1 enhanced the expression of POU2F2, which was validated as a target gene of miR-149-3p.
Causality:Yes
Causal Description:Additionally, ARAP1-AS1 overexpression enhanced the viability, migration, and invasion of CC cells.
Clinical-realted Application: