Entry Detail


General Information

Database ID: LDA0004257
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:AQP4-AS1
Full Name:AQP4 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:C18orf16|CHST9-AS1
Chromosome:18
Strand:+
Coordinate:
Start Site(bp):26865308End Site(bp):26935946
External Links:
Ensembl ID:ENSG00000260372
Ensembl Transcript ID:N/A
Entrez Gene:147429.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Diabetes Mellitus  (Score: 0.731059)
Diabetes Mellitus  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9351D003920
Disease Name:diabetes mellitusDiabetes Mellitus
Category:Disease OntologyMeSH
Type:Nutritional and Metabolic Diseases
Define:A glucose metabolism disease that is characterized by chronic hyperglycaemia with disturbances of carbohydrate, fat and protein metabolism resulting from defects in insulin secretion, insulin action, or both.A heterogeneous group of disorders characterized by HYPERGLYCEMIA and GLUCOSE INTOLERANCE.
Alias:Diabetes Mellitus

 

Disease Association Statistics

Total Associated ncRNA Number:52   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
HAND2-AS1  (Score: 0.731059)
LINC-PINT  (Score: 0.731059)
AQP4-AS1  (Score: 0.731059)
PRINS  (Score: 0.731059)
TINCR  (Score: 0.731059)
HAND2-AS1  (Score: 0.731059)
LINC-PINT  (Score: 0.731059)
AQP4-AS1  (Score: 0.731059)
PRINS  (Score: 0.731059)
TINCR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Transfection
Weak Evidence:

 

Reference

[1] PubMed ID:35172268
Disease Name:Diabetes Mellitus
Sample:clinical samples, Müller cells
Dysfunction Pattern:Regulation(AQP4)
Validated Method:In Vivo Experiment//Transfection
Description:AQP4-AS1 was significantly increased in the clinical samples of diabetic retinopathy patients, high glucose-treated Müller cells, and diabetic retinas of a murine model. Mechanistically, AQP4-AS1 regulated retinal neurovascular dysfunction through affecting AQP4 levels.
Causality:Yes
Causal Description: AQP4-AS1 silencing in vivo alleviated retinal neurodegeneration and vascular dysfunction as shown by improved retinal capillary degeneration, decreased reactive gliosis, and reduced RGC loss. AQP4-AS1 directly regulated Müller cell function and indirectly affected endothelial cell and RGC function in vitro.
Clinical-realted Application: