Entry Detail

General Information

Database ID: LDA0004260
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:APTR
Full Name:Alu-mediated CDKN1A/p21 transcriptional regulator
Category:LncRNA
Species:Homo sapiens
Synonyms:RSBN1L-AS1
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):77657660End Site(bp):77697345
External Links:
Ensembl ID:ENSG00000214293
Ensembl Transcript ID:N/A
Entrez Gene:100505854.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:8   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Osteosarcoma  (Score: 0.731059)
uterine fibroid  (Score: 0.731059)
Osteosarcoma  (Score: 0.731059)
uterine fibroid  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.548294)
Stomach Neoplasms  (Score: 0.548294)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:13223
Disease Name:uterine fibroid
Category:Disease Ontology
Type:Urogenital Diseases
Define:An uterine benign neoplasm derived from the smooth muscle layer of the uterus.
Alias:Plexiform leiomyoma//UTERUS FIBROMA//leiomyoma of Corpus Uteri//uterine leiomyoma

 

Disease Association Statistics

Total Associated ncRNA Number:42   
More Information
Causal ncRNA Number:4
Network:
Top Causal ncRNAs:
hsa_circ_0056686  (Score: 0.985791)
hsa_circ_0056686  (Score: 0.985791)
APTR  (Score: 0.731059)
APTR  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//RIP//FISH//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33777725
Disease Name:uterine fibroid
Sample:UL tumor tissues
Dysfunction Pattern:Interaction(Erα/Wnt pathway )
Validated Method:In Vivo Experiment//Western Blot//RIP//FISH//Luciferase Report Assay//Cell Proliferation Assay//Colony Formation Assay
Description: We found that lncRNA Alu-mediated p21 transcriptional regulator (APTR) showed higher expression in UL tumor tissues compared with that in normal uterine tissues. The results showed that APTR function was suppressed. APTR increased the expressions of the proteins in the Wnt pathway, and inhibiting ERα eliminated these responses. In conclusion, our data suggest that APTR promoted leiomyoma cell proliferation through the Wnt pathway by targeting ERα, suggesting a new role of APTR in the Wnt signaling pathway in UL.
Causality:Yes
Causal Description:APTR induced cell proliferation and colony formation both in vitro and in vivo.
Clinical-realted Application: