Entry Detail

General Information

Database ID: LDA0004262
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:APPAT
Full Name:atherosclerotic plaque pathogenesis associated transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC02969
Chromosome:2
Strand:-
Coordinate:
Start Site(bp):97416165End Site(bp):97424027
External Links:
Ensembl ID:ENSG00000230606
Ensembl Transcript ID:N/A
Entrez Gene:100506123.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:4   
More Information
Causal Disease Number:4
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.731059)
Atherosclerosis  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Atherosclerosis  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1936D050197
Disease Name:atherosclerosisAtherosclerosis
Category:Disease OntologyMeSH
Type:Cardiovascular Diseases
Define:A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA.
Alias:Atherosclerosis//Atheroscleroses//Atherogenesis//Atherogeneses

 

Disease Association Statistics

Total Associated ncRNA Number:206   
More Information
Causal ncRNA Number:96
Network:
Top Causal ncRNAs:
XIST  (Score: 0.999893)
H19  (Score: 0.999893)
XIST  (Score: 0.999893)
H19  (Score: 0.999893)
MIAT  (Score: 0.985791)
TUG1  (Score: 0.985791)
MIAT  (Score: 0.985791)
PVT1  (Score: 0.985791)
TUG1  (Score: 0.985791)
PVT1  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35880306
Disease Name:Atherosclerosis
Sample:HASMCs
Dysfunction Pattern:Interaction(miR-647)
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//MTT//Luciferase Report Assay//EdU Staining//Transwell Assay
Description:APPAT and miR-647 have inverse effects on human aortic smooth muscle cells' (HASMCs) proliferation and migration. APPAT negatively regulated the cell activity, whereas miR-647 did it in a positive way (p<0.05). Three pairs of molecular interplay were found: mutual negative regulation between APPAT and miR-647, APPAT downregulated FGF5, miR-647 regulation on FGF5 (p<0.05). Subcellular location assay confirmed the molecular interaction of APPAT and miR-647.
Causality:Yes
Causal Description:APPAT and miR-647 have inverse effects on human aortic smooth muscle cells' (HASMCs) proliferation and migration. APPAT negatively regulated the cell activity, whereas miR-647 did it in a positive way (p<0.05).
Clinical-realted Application: