Entry Detail

General Information

Database ID: LDA0004277
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:AGO2
Full Name:argonaute RISC catalytic component 2
Category:LncRNA
Species:Homo sapiens
Synonyms:CASC7|EIF2C2|LESKRES|LINC00980|PPD|Q10
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):140520156End Site(bp):140642313
External Links:
Ensembl ID:ENSG00000123908
Ensembl Transcript ID:N/A
Entrez Gene:27161.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Glioma  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
Neuroblastoma  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D005910
Disease Name:Glioma
Category:MeSH
Type:Neoplasms
Define:Benign and malignant central nervous system neoplasms derived from glial cells (i.e., astrocytes, oligodendrocytes, and ependymocytes). Astrocytes may give rise to astrocytomas (ASTROCYTOMA) or glioblastoma multiforme (see GLIOBLASTOMA). Oligodendrocytes give rise to oligodendrogliomas (OLIGODENDROGLIOMA) and ependymocytes may undergo transformation to become EPENDYMOMA; CHOROID PLEXUS NEOPLASMS; or colloid cysts of the third ventricle. (From Escourolle et al., Manual of Basic Neuropathology, 2nd ed, p21)
Alias:Glioma//Gliomas//Glial Cell Tumors//Glial Cell Tumor//Tumor, Glial Cell//Tumors, Glial Cell//Mixed Glioma//Glioma, Mixed//Gliomas, Mixed//Mixed Gliomas//Malignant Glioma//Glioma, Malignant//Gliomas, Malignant//Malignant Gliomas

 

Disease Association Statistics

Total Associated ncRNA Number:660   
More Information
Causal ncRNA Number:606
Network:
Top Causal ncRNAs:
H19  (Score: 1)
H19  (Score: 1)
MEG3  (Score: 1)
UCA1  (Score: 1)
UCA1  (Score: 1)
GAS5  (Score: 1)
FOXD2-AS1  (Score: 1)
NEAT1  (Score: 1)
MEG3  (Score: 1)
PVT1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//qPCR//CCK8//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay
Weak Evidence:

 

Reference

[1] PubMed ID:30661904
Disease Name:Glioma
Sample:glioma tissues and cell lines
Dysfunction Pattern:Regulation[Wnt/β-catenin signaling pathway]
Validated Method:Western Blot//qPCR//CCK8//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay
Description:We found that CASC7 was downregulated in glioma tissues and cell liens and predicted poor prognosis for patients with glioma. Taken together, all research findings suggested that CASC7 inhibited the progression of glioma via regulating Wnt/β-catenin signaling pathway.
Causality:Yes
Causal Description: To determine the involvement of CASC7 in the biological processes of glioma, we conducted gain or loss-of function assays in two glioma patients. We found that CASC7 suppressed glioma cell proliferation and induced glioma cell apoptosis.
Clinical-realted Application:We found that CASC7 was downregulated in glioma tissues and cell liens and predicted poor prognosis for patients with glioma.