Entry Detail

General Information

Database ID: LDA0004278
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:AGO2
Full Name:argonaute RISC catalytic component 2
Category:LncRNA
Species:Homo sapiens
Synonyms:CASC7|EIF2C2|LESKRES|LINC00980|PPD|Q10
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):140520156End Site(bp):140642313
External Links:
Ensembl ID:ENSG00000123908
Ensembl Transcript ID:N/A
Entrez Gene:27161.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:14   
More Information
Causal Disease Number:14
Network:
Top Causal Diseases:
Breast Neoplasms  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Glioma  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Thyroid Cancer, Papillary  (Score: 0.731059)
Neuroblastoma  (Score: 0.731059)
Breast Neoplasms  (Score: 0.731059)
Colonic Neoplasms  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3908D002289
Disease Name:lung non-small cell carcinomaCarcinoma, Non-Small-Cell Lung
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A lung carcinoma that is characterized as any type of epithelial lung cancer other than small cell lung carcinoma.A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
Alias:NSCLC//Non-small cell lung cancer//non-small cell lung carcinomaCarcinoma, Non-Small-Cell Lung//Carcinoma, Non Small Cell Lung//Carcinomas, Non-Small-Cell Lung//Lung Carcinoma, Non-Small-Cell//Lung Carcinomas, Non-Small-Cell//Non-Small-Cell Lung Carcinomas//Non-Small-Cell Lung Carcinoma//Non Small Cell Lung Carcinoma//Carcinoma, Non-Small Cell Lung//Non-Small Cell Lung Carcinoma//Non-Small Cell Lung Cancer//Nonsmall Cell Lung Cancer

 

Disease Association Statistics

Total Associated ncRNA Number:1090   
More Information
Causal ncRNA Number:936
Network:
Top Causal ncRNAs:
AFAP1-AS1  (Score: 1)
FEZF1-AS1  (Score: 1)
BCYRN1  (Score: 1)
GAS5  (Score: 1)
MALAT1  (Score: 1)
MAGI2-AS3  (Score: 1)
AWPPH  (Score: 1)
DANCR  (Score: 1)
hsa_circ_0007385  (Score: 1)
hsa_circ_0074027  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//ISH//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32626930
Disease Name:Carcinoma, Non-Small-Cell Lung
Sample:NSCLC tissues and cell lines
Dysfunction Pattern:interaction[sponging miR-92a]
Validated Method:Western Blot//ISH//Wound Healing Assay//qRT-PCR//MTT//Luciferase Report Assay//Transwell Assay
Description:Marked downregulation of CASC7 was observed in NSCLC tissues and cell lines, and this downregulation of CASC7 was closely associated with distant metastasis, lymph node involvement and poor overall survival in NSCLC patients. Collectively, the results of the present study indicated that CASC7 may act as a tumor‑suppressive lncRNA that inhibits NSCLC progression by sponging miR‑92a.
Causality:Yes
Causal Description: Furthermore, overexpression of CASC7 significantly suppressed the proliferation, invasion and migration of the NSCLC cells A549 and H358, and promoted cell apoptosis in vitro.
Clinical-realted Application:Marked downregulation of CASC7 was observed in NSCLC tissues and cell lines, and this downregulation of CASC7 was closely associated with distant metastasis, lymph node involvement and poor overall survival in NSCLC patients.