Entry Detail

General Information

Database ID: LDA0004451
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ABCB10
Full Name:ATP binding cassette subfamily B member 10
Category:LncRNA
Species:Homo sapiens
Synonyms:EST20237|M-ABC2|MTABC2
Chromosome:1
Strand:-
Coordinate:
Start Site(bp):229516582End Site(bp):229558707
External Links:
Ensembl ID:ENSG00000135776
Ensembl Transcript ID:N/A
Entrez Gene:23456.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:6   
More Information
Causal Disease Number:6
Network:
Top Causal Diseases:
Carcinoma, Ovarian Epithelial  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
Carcinoma, Ovarian Epithelial  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5520D000077195
Disease Name:head and neck squamous cell carcinomaSquamous Cell Carcinoma of Head and Neck
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A head and neck carcinoma that has_material_basis_in squamous cells that line the moist, mucosal surfaces inside the head and neck.The most common type of head and neck carcinoma that originates from cells on the surface of the NASAL CAVITY; MOUTH; PARANASAL SINUSES, SALIVARY GLANDS, and LARYNX. Mutations in TNFRSF10B, PTEN, and ING1 genes are associated with this cancer.
Alias:carcinoma of the head and neck//squamous cell carcinoma of the head and neck//squamous cell carcinomas of head and neckSquamous Cell Carcinoma of Head and Neck//Head And Neck Squamous Cell Carcinomas//Squamous Cell Carcinoma, Head And Neck//Squamous Cell Carcinoma of the Head and Neck//Head and Neck Squamous Cell Carcinoma//HNSCC//Carcinoma, Squamous Cell of Head and Neck//Squamous Cell Carcinoma of the Larynx//Laryngeal Squamous Cell Carcinoma//Squamous Cell Carcinoma of Larynx//Squamous Cell Carcinoma of the Nasal Cavity//Oral Tongue Squamous Cell Carcinoma//Hypopharyngeal Squamous Cell Carcinoma//Oral Squamous Cell Carcinoma//Oral Cavity Squamous Cell Carcinoma//Oral Squamous Cell Carcinomas//Squamous Cell Carcinoma of the Mouth//Oropharyngeal Squamous Cell Carcinoma

 

Disease Association Statistics

Total Associated ncRNA Number:632   
More Information
Causal ncRNA Number:464
Network:
Top Causal ncRNAs:
XIST  (Score: 1)
CYTOR  (Score: 1)
hsa_circ_0001971  (Score: 1)
MALAT1  (Score: 1)
GAS5  (Score: 1)
HOXA11-AS  (Score: 1)
NORAD  (Score: 1)
MEG3  (Score: 1)
NEAT1  (Score: 1)
CYTOR  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:colony Formation Assay//Western Blot//Wound Healing Assay//qRT-PCR//RIP//IF//MTT//PCR//IP//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34015764
Disease Name:Squamous Cell Carcinoma of Head and Neck
Sample:LSCC cells
Dysfunction Pattern:Interaction(miR-588/CXCR4 axis)
Validated Method:colony Formation Assay//Western Blot//Wound Healing Assay//Colony Formation Assay//qRT-PCR//RIP//MTT//PCR//IP//Transwell Assay//IF
Description:Here, we were interested in the role of circABCB10 in the modulation of LSCC progression. Mechanically, circABCB10 served as a sponge for microRNAs-588 (miR-588) and miR-588 could target and down-regulated chemokine receptor 4 (CXCR4) expression in LSCC cells. Thus, we concluded that circABCB10 was involved in the malignant progression of LSCC by regulating miR-588/CXCR4 axis.
Causality:Yes
Causal Description:Our data demonstrated that the depletion of circABCB10 significantly inhibited the proliferation and induced the apoptosis of LSCC cells.Meanwhile, circABCB10 knockdown was able to remarkably reduce the invasion and migration of LSCC cells.
Clinical-realted Application: