Entry Detail

General Information

Database ID: LDA0004461
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ARHGAP42
Full Name:Rho GTPase activating protein 42
Category:LncRNA
Species:Homo sapiens
Synonyms:AD031|GRAF3|TMEM133
Chromosome:11
Strand:+
Coordinate:
Start Site(bp):100687288End Site(bp):100993941
External Links:
Ensembl ID:ENSG00000165895
Ensembl Transcript ID:N/A
Entrez Gene:143872.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Nasopharyngeal carcinoma  (Score: 0.731059)
Nasopharyngeal carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9261C538339
Disease Name:nasopharynx carcinomaNasopharyngeal carcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A pharynx cancer that is located in the nasopharynx, the uppermost region of the pharynx or throat, where the nasal passages and auditory tubes join the remainder of the upper respiratory tract.A carcinoma that originates in the nasopharyngeal EPITHELIUM and includes 4 subtypes: keratinizing squamous cell, nonkeratinizing, basaloid squamous cell, and PAPILLARY ADENOCARCINOMA. It is most prevalent in Southeast Asian populations and is associated with EPSTEIN-BARR VIRUS INFECTIONS. Somatic mutations have been identified in NPCR, BAP1, UBAP1, ERBB2, ERBB3, MLL2, PIK3CA, KRAS, NRAS, and ARID1A genes. OMIM: 607107
Alias:Nasopharyngeal carcinoma//malignant Nasopharyngeal tumor//malignant neoplasm of nasopharynx//nasopharynx cancer

 

Disease Association Statistics

Total Associated ncRNA Number:260   
More Information
Causal ncRNA Number:244
Network:
Top Causal ncRNAs:
ZFAS1  (Score: 1)
ZFAS1  (Score: 1)
DANCR  (Score: 0.999893)
XIST  (Score: 0.999893)
XIST  (Score: 0.999893)
DANCR  (Score: 0.999893)
circZNF609  (Score: 0.985791)
hsa_circ_0008450  (Score: 0.985791)
PVT1  (Score: 0.985791)
circZNF609  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot//IHC//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:29936709
Disease Name:Nasopharyngeal carcinoma
Sample:nasopharyngeal carcinoma tissues and cell lines
Dysfunction Pattern:Regulation[PI3K/Akt signaling pathway]
Validated Method:Transwell Assay//qRT-PCR//IHC//Western Blot
Description:We confirmed the elevated expression of ARHGAP42 in metastatic NPC tissues of mRNA and protein for the first time.
Causality:Yes
Causal Description:Knockdown of ARHGAP42 resulted in significant inhibition of nasopharyngeal cancer cell migration and invasion in vitro, and the overexpression of ARHGAP42 showed the opposite effects.
Clinical-realted Application:Immunohistochemical analysis indicated that NPC patients with highly ARHGAP42 expression were significantly associated with shorter metastasis-free survival.