Entry Detail

General Information

Database ID: LDA0004462
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CASC15
Full Name:cancer susceptibility 15
Category:LncRNA
Species:Homo sapiens
Synonyms:CANT|LINC00340|lnc-SOX4-1
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):21666413End Site(bp):22195820
External Links:
Ensembl ID:ENSG00000272168
Ensembl Transcript ID:N/A
Entrez Gene:401237.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:34   
More Information
Causal Disease Number:28
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.985791)
tongue squamous cell carcinoma  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
tongue squamous cell carcinoma  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:0050865
Disease Name:tongue squamous cell carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A head and neck squamous cell carcinoma that is located_in the tongue.
Alias:

 

Disease Association Statistics

Total Associated ncRNA Number:140   
More Information
Causal ncRNA Number:70
Network:
Top Causal ncRNAs:
hsa_circ_0001742  (Score: 1)
hsa_circ_0001742  (Score: 1)
MALAT1  (Score: 1)
MALAT1  (Score: 1)
CASC15  (Score: 0.985791)
hsa_circ_0002162  (Score: 0.985791)
CASC15  (Score: 0.985791)
hsa_circ_0000231  (Score: 0.985791)
hsa_circ_0002162  (Score: 0.985791)
hsa_circ_0000231  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:31665008
Disease Name:tongue squamous cell carcinoma
Sample:TSCC tissues
Dysfunction Pattern:Interaction[downregulate miR-124]
Validated Method:qRT-PCR
Description:We found that CASC15 was upregulated, while miR-124 was downregulated in TSCC tissues than in non-cancer tissues of TSCC patients. CASC15 and miR-124 predict TSCC patients' survival and CASC15 may downregulate miR-124 to inhibit TSCC cell migration and invasion.
Causality:Yes
Causal Description:CASC15 overexpression resulted in the increased, while miR-124 overexpression resulted in the decreased migration and invasion rates of TSCC cells.
Clinical-realted Application:

[2] PubMed ID:29804249
Disease Name:tongue squamous cell carcinoma
Sample:TSCC samples and cell lines
Dysfunction Pattern:interaction[miR-33a-5p]
Validated Method:qRT-PCR//Western Blot
Description:Here, we identified that CASC15 expression was upregulated in TSCC samples and cell lines. These results suggested that lncRNA CASC15 and miR-33a-5p might be exploited as new markers of TSCC and were potential treatment targets for TSCC patients.
Causality:Yes
Causal Description:We showed that overexpression of CASC15 promoted cell proliferation, cycle, and migration in TSCC.
Clinical-realted Application: