Entry Detail

General Information

Database ID: LDA0004476
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CASC11
Full Name:cancer susceptibility 11
Category:LncRNA
Species:Homo sapiens
Synonyms:CARLO7|CARLo-7|LINC00990|MYMLR|TCONS_00014535
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):127700608End Site(bp):127733967
External Links:
Ensembl ID:ENSG00000249375
Ensembl Transcript ID:N/A
Entrez Gene:100270680.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:34   
More Information
Causal Disease Number:26
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Urinary Bladder Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.731059)
esophageal carcinoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D055752
Disease Name:Small Cell Lung Carcinoma
Category:MeSH
Type:Neoplasms
Define:A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
Alias:Small Cell Lung Carcinoma//Small Cell Lung Cancer//Oat Cell Lung Cancer//Small Cell Cancer Of The Lung//Carcinoma, Small Cell Lung//Oat Cell Carcinoma of Lung

 

Disease Association Statistics

Total Associated ncRNA Number:28   
More Information
Causal ncRNA Number:24
Network:
Top Causal ncRNAs:
circPVT1  (Score: 0.731059)
KCNQ1OT1  (Score: 0.731059)
LUADT1  (Score: 0.731059)
LINC01555  (Score: 0.731059)
LINC01116  (Score: 0.731059)
CASC11  (Score: 0.731059)
ZFPM2-AS1  (Score: 0.731059)
MCM3AP-AS1  (Score: 0.731059)
NEF  (Score: 0.731059)
HIF1A-AS2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:30965130
Disease Name:Small Cell Lung Carcinoma
Sample:blood
Dysfunction Pattern:Interaction[TGF-β1]
Validated Method:qRT-PCR
Description:Plasma CASC11 and TGF-β1 were upregulated and positively correlated in SCLC patients, but not in healthy controls. Overexpression of CASC11 and TGF-β1 also resulted in the increased percentage of CDD133+ cells of SCLC cell lines, while TGF-β inhibitor attenuated the effects of CASC11 overexpression. CASC11 overexpression mediated the upregulation of TGF-β1 in SCLC cells, while treatment with exogenous TGF-β1 showed no significant effect on CASC11.
Causality:Yes
Causal Description:Overexpression of CASC11 and TGF-β1 also resulted in the increased percentage of CDD133+ cells of SCLC cell lines, while TGF-β inhibitor attenuated the effects of CASC11 overexpression.
Clinical-realted Application:Upregulation of plasma CASC11 and TGF-β1 predicted poor survival of SCLC patients.