Entry Detail

General Information

Database ID: LDA0004477
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CASC11
Full Name:cancer susceptibility 11
Category:LncRNA
Species:Homo sapiens
Synonyms:CARLO7|CARLo-7|LINC00990|MYMLR|TCONS_00014535
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):127700608End Site(bp):127733967
External Links:
Ensembl ID:ENSG00000249375
Ensembl Transcript ID:N/A
Entrez Gene:100270680.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:34   
More Information
Causal Disease Number:26
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.999893)
Carcinoma, Hepatocellular  (Score: 0.999893)
Urinary Bladder Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Prostatic Neoplasms  (Score: 0.985791)
Urinary Bladder Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.731059)
esophageal carcinoma  (Score: 0.731059)
Glioma  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3829D010911
Disease Name:pituitary adenomaPituitary Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A pituitary gland benign neoplasm that derives_from glandular epithelial cells.Neoplasms which arise from or metastasize to the PITUITARY GLAND. The majority of pituitary neoplasms are adenomas, which are divided into non-secreting and secreting forms. Hormone producing forms are further classified by the type of hormone they secrete. Pituitary adenomas may also be characterized by their staining properties (see ADENOMA, BASOPHIL; ADENOMA, ACIDOPHIL; and ADENOMA, CHROMOPHOBE). Pituitary tumors may compress adjacent structures, including the HYPOTHALAMUS, several CRANIAL NERVES, and the OPTIC CHIASM. Chiasmal compression may result in bitemporal HEMIANOPSIA.
Alias:adenoma of the Pituitary glandPituitary Neoplasms//Neoplasm, Pituitary//Neoplasms, Pituitary//Pituitary Neoplasm//Pituitary Tumors//Pituitary Tumor//Tumor, Pituitary//Tumors, Pituitary//Pituitary Adenoma//Adenoma, Pituitary//Adenomas, Pituitary//Pituitary Adenomas//Pituitary Carcinoma//Carcinoma, Pituitary//Carcinomas, Pituitary//Pituitary Carcinomas//Cancer of the Pituitary//Pituitary Cancer//Cancer, Pituitary//Cancers, Pituitary//Cancer of Pituitary//Pituitary Cancers

 

Disease Association Statistics

Total Associated ncRNA Number:336   
More Information
Causal ncRNA Number:32
Network:
Top Causal ncRNAs:
MEG3  (Score: 0.985791)
MEG3  (Score: 0.985791)
LINC01004  (Score: 0.731059)
H19  (Score: 0.731059)
AFAP1-AS1  (Score: 0.731059)
CASC11  (Score: 0.731059)
BBOX1-AS1  (Score: 0.731059)
RPSAP52  (Score: 0.731059)
circVPS13C  (Score: 0.731059)
SNHG6  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//Colony Formation Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//IHC//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:36206098
Disease Name:Pituitary Neoplasms
Sample:PA tissues and cell
Dysfunction Pattern:Interaction( lncRNA MYMLR/miR-197-3p/CBR1)
Validated Method:In Vivo Experiment//IHC//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Luciferase Report Assay//Cell Apoptosis Assay//Colony Formation Assay//Transwell Assay
Description: LncRNA MYMLR was highly expressed in PA tissues compared with that in normal tissues. Mechanistically, MYMLR functioned as a competing endogenous RNA (ceRNA) sponging microRNA miR-197-3p. Furthermore, miR-197-3p exerted its tumor inhibitory role via negatively regulating carbonyl reductase 1 (CBR1). Overexpression of CBR1 antagonized the inhibitory effect of lncRNA MYMLR knockdown or miR-197-3p overexpression. In addition, xenograft tumor model revealed that knockdown of lncRNA MYMLR suppressed PA tumor development in vivo via regulating CBR1.
Causality:Yes
Causal Description: Knockdown of MYMLR suppressed cell proliferation, migration and invasion, while promoting PA cell apoptosis.
Clinical-realted Application: