Entry Detail

General Information

Database ID: LDA0004490
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CASC15
Full Name:cancer susceptibility 15
Category:LncRNA
Species:Homo sapiens
Synonyms:CANT|LINC00340|lnc-SOX4-1
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):21666413End Site(bp):22195820
External Links:
Ensembl ID:ENSG00000272168
Ensembl Transcript ID:N/A
Entrez Gene:401237.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:34   
More Information
Causal Disease Number:28
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Esophageal Squamous Cell Carcinoma  (Score: 0.999893)
Breast Neoplasms  (Score: 0.999893)
Uterine Cervical Neoplasms  (Score: 0.985791)
tongue squamous cell carcinoma  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
tongue squamous cell carcinoma  (Score: 0.985791)
Uterine Cervical Neoplasms  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D000077273
Disease Name:Thyroid Cancer, Papillary
Category:MeSH
Type:Neoplasms
Define:An ADENOCARCINOMA that originates from follicular cells of the THYROID GLAND and accounts for the majority of THYROID CANCER cases. Cells exhibit enlarged, oval, or elongated morphologies with clear, round, nuclei. Fusions of RET, NTRK1, TPM3, and PCM1 genes are associated with this cancer.
Alias:Thyroid Cancer, Papillary//Cancer, Papillary Thyroid//Cancers, Papillary Thyroid//Papillary Thyroid Cancer//Papillary Thyroid Cancers//Thyroid Cancers, Papillary//Thyroid Carcinoma, Papillary//Carcinoma, Papillary Thyroid//Carcinomas, Papillary Thyroid//Papillary Thyroid Carcinomas//Thyroid Carcinomas, Papillary//Papillary Carcinoma Of Thyroid//Papillary Thyroid Carcinoma//Familial Nonmedullary Thyroid Cancer//Nonmedullary Thyroid Carcinoma//Carcinoma, Nonmedullary Thyroid//Carcinomas, Nonmedullary Thyroid//Nonmedullary Thyroid Carcinomas//Thyroid Carcinoma, Nonmedullary//Thyroid Carcinomas, Nonmedullary

 

Disease Association Statistics

Total Associated ncRNA Number:340   
More Information
Causal ncRNA Number:280
Network:
Top Causal ncRNAs:
UCA1  (Score: 0.999893)
UCA1  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
LINC00460  (Score: 0.999893)
HOTAIR  (Score: 0.999893)
LINC00460  (Score: 0.999893)
BICDL3P  (Score: 0.999358)
BICDL3P  (Score: 0.999358)
hsa_circ_0000644  (Score: 0.985791)
circRAPGEF5  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Colony Formation Assay//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:34325316
Disease Name:Thyroid Cancer, Papillary
Sample:PTC tissues
Dysfunction Pattern:Interaction(miR-7151-5p/WNT7A axis)
Validated Method:qRT-PCR//Colony Formation Assay//Western Blot
Description: The present study results showed that CASC15 was overexpressed in PTC tissues compared with normal tissues and acted as a potent oncogene to promote the proliferation and tumorigenesis of PTC cells both in vitro and in vivo. Mechanistic studies demonstrated that CASC15 could serve as an endogenous miRNA sponge to absorb and downregulate miR-7151-5p, thereby preventing the inhibition of WNT7A during PTC progression. Furthermore, the study demonstrated that CASC15 activated the WNT/β‑catenin signaling pathway by upregulating WNT7A in PTC.
Causality:Yes
Causal Description:The present study results showed that CASC15 was overexpressed in PTC tissues compared with normal tissues and acted as a potent oncogene to promote the proliferation and tumorigenesis of PTC cells both in vitro and in vivo.
Clinical-realted Application: