Entry Detail

General Information

Database ID: LDA0004510
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:BTN3A2
Full Name:butyrophilin subfamily 3 member A2
Category:LncRNA
Species:Homo sapiens
Synonyms:BT3.2|BTF4|BTN3.2|CD277
Chromosome:6
Strand:+
Coordinate:
Start Site(bp):26365169End Site(bp):26378320
External Links:
Ensembl ID:ENSG00000186470
Ensembl Transcript ID:N/A
Entrez Gene:11118.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Bacterial Infections  (Score: 0.731059)
Bacterial Infections  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D001424
Disease Name:Bacterial Infections
Category:MeSH
Type:Infections
Define:Infections by bacteria, general or unspecified.
Alias:Bacterial Infections//Infections, Bacterial//Infection, Bacterial//Bacterial Disease//Bacterial Diseases//Bacterial Infection

 

Disease Association Statistics

Total Associated ncRNA Number:2   
More Information
Causal ncRNA Number:2
Network:
Top Causal ncRNAs:
BTN3A2  (Score: 0.731059)
BTN3A2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//qRT-PCR//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:36091044
Disease Name:Bacterial Infections
Sample:cecum tissue and DF-1 cells
Dysfunction Pattern:Expression(highly expressed)
Validated Method:In Vivo Experiment//qRT-PCR//ELISA//RNA-seq
Description: Moreover, through cis regulation network analysis of the differentially expressed lncRNAs, we found that a novel lncRNA termed lncRNA BTN3A2 was significantly increased in both cecum tissue and DF-1 cells after coccidia infection or sporozoite stimulation.
Causality:Yes
Causal Description:Functional test data showed that the overexpression of lncRNA BTN3A2 reduced the production of inflammatory cytokines, including IL-6, IL-1β, TNF-α and IL-8, while lncRNA BTN3A2 knockdown promoted the production of these inflammatory cytokines.
Clinical-realted Application: