Entry Detail

General Information

Database ID: LDA0004518
Species: Homo sapiens
Confidence Score: 0.959542
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CARMN
Full Name:cardiac mesoderm enhancer-associated non-coding RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:CARMEN|MIR143HG
Chromosome:5
Strand:+
Coordinate:
Start Site(bp):149406845End Site(bp):149432836
External Links:
Ensembl ID:ENSG00000249669
Ensembl Transcript ID:N/A
Entrez Gene:728264.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:18   
More Information
Causal Disease Number:12
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 0.985791)
Carcinoma, Hepatocellular  (Score: 0.985791)
Endometrial Neoplasms  (Score: 0.959542)
Endometrial Neoplasms  (Score: 0.959542)
Urinary Bladder Neoplasms  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Glioblastoma  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1380D016889
Disease Name:endometrial cancerEndometrial Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A uterine cancer that is located_in tissues lining the uterus.Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
Alias:endometrial Ca//endometrial neoplasm//malignant endometrial neoplasm//malignant neoplasm of endometrium//neoplasm of endometrium//primary malignant neoplasm of endometrium//tumor of EndometriumEndometrial Neoplasms//Endometrial Neoplasm//Neoplasm, Endometrial//Neoplasms, Endometrial//Endometrial Carcinoma//Carcinoma, Endometrial//Carcinomas, Endometrial//Endometrial Carcinomas//Endometrial Cancer//Cancer, Endometrial//Cancers, Endometrial//Endometrial Cancers//Endometrium Cancer//Cancer, Endometrium//Cancers, Endometrium//Cancer of the Endometrium//Carcinoma of Endometrium//Endometrium Carcinoma//Endometrium Carcinomas//Cancer of Endometrium//Endometrium Cancers

 

Disease Association Statistics

Total Associated ncRNA Number:232   
More Information
Causal ncRNA Number:178
Network:
Top Causal ncRNAs:
DLEU1  (Score: 0.999893)
hsa_circ_0000437  (Score: 0.999893)
hsa_circ_0000437  (Score: 0.999893)
DLEU1  (Score: 0.999893)
hsa_circ_0001776  (Score: 0.985791)
PCAT1  (Score: 0.985791)
hsa_circ_0001776  (Score: 0.985791)
PCAT1  (Score: 0.985791)
hsa_circ_0001610  (Score: 0.985791)
hsa_circ_0075960  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR//Cell Apoptosis Assay//Western Blot
Weak Evidence:RNA-seq

 

Reference

[1] PubMed ID:31819644
Disease Name:Endometrial Neoplasms
Sample:EC tissues
Dysfunction Pattern:Interaction[sponging miR-125a ]
Validated Method:qRT-PCR//Cell Apoptosis Assay//Western Blot
Description:We found that the down-regulation of miR143HG in EC predicted poor survival.MiR143HG may up-regulate p53 in EC by sponging miR-125a to promote cancer cell apoptosis.
Causality:Yes
Causal Description:Cell apoptosis analysis showed that miR143HG and p53 over-expression led to an increased cell apoptotic rate.
Clinical-realted Application:We found that the down-regulation of miR143HG in EC predicted poor survival.

[2] PubMed ID:36510632
Disease Name:Endometrial Neoplasms
Sample:Serum and tissue samples
Dysfunction Pattern:Expression(lower expressed)
Validated Method:RNA-seq
Description:At the same time, lncRNA sequencing results showed that when endometrial atypical hyperplasia continued to change, including LINC00511, PVT1, and IQCH-AS1 (downregulated), and only changed significantly in the endometrial dysplasia group, including MALAT1, CARMN (downregulated) and LINC00648, BISPR, LINC01534, and LINC00930 (upregulated).
Causality:No
Causal Description:
Clinical-realted Application: