Entry Detail

General Information

Database ID: LDA0004524
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CARD11
Full Name:caspase recruitment domain family member 11
Category:LncRNA
Species:Homo sapiens
Synonyms:BENTA|BIMP3|CARMA1|IMD11|IMD11A|PPBL
Chromosome:7
Strand:-
Coordinate:
Start Site(bp):2906142End Site(bp):3043867
External Links:
Ensembl ID:ENSG00000198286
Ensembl Transcript ID:N/A
Entrez Gene:84433.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Uveal melanoma  (Score: 0.731059)
Uveal melanoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:6039C536494
Disease Name:uveal melanomaUveal melanoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A uveal cancer that has_material_basis_in uvea pigment cells.A melanoma that originates from uveal MELANOCYTES and is the most common primary intraocular malignancy. Tumors consist of four cell types: epitheloid, intermediate, mixed, and spindle. Somatic mutations in BAP1, GNAQ, GNA11, EIF1AX, and SF3B1 genes have been identified. OMIM: 155720
Alias:melanoma of Uvea

 

Disease Association Statistics

Total Associated ncRNA Number:14   
More Information
Causal ncRNA Number:14
Network:
Top Causal ncRNAs:
PVT1  (Score: 0.985791)
PVT1  (Score: 0.985791)
GAS5  (Score: 0.731059)
LOC100132707  (Score: 0.731059)
CARD11  (Score: 0.731059)
hsa_circ_0119872  (Score: 0.731059)
SNHG7  (Score: 0.731059)
GAS5  (Score: 0.731059)
LOC100132707  (Score: 0.731059)
CARD11  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:34370778
Disease Name:Uveal melanoma
Sample:immune cells
Dysfunction Pattern:Expression(highly expressed)
Validated Method:qRT-PCR
Description:CARD11 expression had notable correlation with UVM clinicopathological features, which was also an independent predictor for overall survival (OS). Intriguingly, CARD11 had a positively correlation to autophagy, cellular senescence and apoptosis. Infiltration of monocytes was significantly higher in low CARD11 expression group, and infiltration of T cells regulatory was lower in the same group. Functional enrichment analyses revealed that CARD11 was positively related to T cell activation pathways and cell adhesion molecules. The expressions of hub-genes were all increased in the high CARD11 expression group and the ceRNA network showed the interaction among mRNA, miRNA and lncRNA. These findings show that high CARD11 expression in UVM is associated with poor OS
Causality:Yes
Causal Description:Functional enrichment analyses revealed that CARD11 was positively related to T cell activation pathways and cell adhesion molecules. The expressions of hub-genes were all increased in the high CARD11 expression group and the ceRNA network showed the interaction among mRNA, miRNA and lncRNA.
Clinical-realted Application:high CARD11 expression in UVM is associated with poor OS