Entry Detail

General Information

Database ID: LDA0004553
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CASC9
Full Name:cancer susceptibility 9
Category:LncRNA
Species:Homo sapiens
Synonyms:ESCCAL-1|ESSCAL1|LINC00981|linc-JPH1
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):75223117End Site(bp):75278889
External Links:
Ensembl ID:ENSG00000249395
Ensembl Transcript ID:N/A
Entrez Gene:101805492.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:40   
More Information
Causal Disease Number:40
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 1)
Breast Neoplasms  (Score: 1)
Esophageal Squamous Cell Carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Urinary Bladder Neoplasms  (Score: 0.999893)
Urinary Bladder Neoplasms  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:552D011014
Disease Name:pneumoniaPneumonia
Category:Disease OntologyMeSH
Type:Infections
Define:A lung disease that involves lung parenchyma or alveolar inflammation and abnormal alveolar filling with fluid (consolidation and exudation). It results from a variety of causes including infection with bacteria, viruses, fungi or parasites, and chemical or physical injury to the lungs. It is accompanied by fever, chills, cough, and difficulty in breathing.Infection of the lung often accompanied by inflammation.
Alias:acute pneumoniaPneumonia//Pneumonias//Lobar Pneumonia//Lobar Pneumonias//Pneumonias, Lobar//Pneumonia, Lobar//Experimental Lung Inflammation//Experimental Lung Inflammations//Inflammation, Experimental Lung//Lung Inflammation, Experimental//Lung Inflammations, Experimental//Pneumonitis//Pneumonitides//Pulmonary Inflammation//Inflammation, Pulmonary//Inflammations, Pulmonary//Pulmonary Inflammations//Lung Inflammation//Inflammation, Lung//Inflammations, Lung//Lung Inflammations

 

Disease Association Statistics

Total Associated ncRNA Number:12   
More Information
Causal ncRNA Number:10
Network:
Top Causal ncRNAs:
H19  (Score: 0.985791)
H19  (Score: 0.985791)
CASC9  (Score: 0.731059)
SNHG16  (Score: 0.731059)
hsa_circ_0026579  (Score: 0.731059)
hsa_circ_0038467  (Score: 0.731059)
CASC9  (Score: 0.731059)
SNHG16  (Score: 0.731059)
hsa_circ_0026579  (Score: 0.731059)
hsa_circ_0038467  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Transfection//CCK8//qRT-PCR//Cell Apoptosis Assay//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:35587261
Disease Name:Pneumonia
Sample:serum samples
Dysfunction Pattern:Expression(lower expressed)
Validated Method:Transfection//CCK8//qRT-PCR//Cell Apoptosis Assay//ELISA
Description:The relative expression of CASC9 was downregulated in serum samples of severe pneumonia patients.
Causality:Yes
Causal Description:The elevated expression of CASC9 accelerated cell viability and diminished apoptosis in LPS-induced MRC-5 cells. The CASC9 expression was decreased in serum samples of severe pneumonia, and upregulation of CASC9 facilitated LPS-induced cell viability and inhibited apoptosis.
Clinical-realted Application:The low expression of CASC9 in severe pneumonia was negatively correlated with several clinical data. The CASC9 had the relatively high area under ROC curve (AUC) values for distinguishing severe pneumonia from pneumonia children and healthy control.