LncRNADisease3

Entry Detail

General Information

Database ID:	LDA0004559
Species:	Homo sapiens
Confidence Score:	0.731059
Contents:	>> ncRNA Information >> ncRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference
Causality:	Yes
Clinical Significance:	Unknown

ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:

CBR3-AS1

Full Name:

CBR3 antisense RNA 1

Category:

LncRNA

Species:

Homo sapiens

Synonyms:

PlncRNA-1|PlncRNA1

Chromosome:

Strand:

Coordinate:

Start Site(bp):

36131767

End Site(bp):

36156308

External Links:

Ensembl ID:	ENSG00000236830
Ensembl Transcript ID:	N/A
Entrez Gene:	100506428.0
NONCODE ID:	N/A
RefSeq Accession:	N/A

ncRNA Association Statistics

Total Associated Disease Number:

20 More Information

Causal Disease Number:

Network:

Top Causal Diseases:

Breast Neoplasms (Score: 0.999893)

Colorectal Neoplasms (Score: 0.985791)

Osteosarcoma (Score: 0.731059)

Adenocarcinoma of Lung (Score: 0.731059)

Prostatic Neoplasms (Score: 0.731059)

gestational choriocarcinoma (Score: 0.731059)

Urinary Bladder Neoplasms (Score: 0.731059)

Carcinoma, Non-Small-Cell Lung (Score: 0.731059)

More Information

Disease Information

	Disease Ontology	MeSH
Disease ID:	DOID:2025
Disease Name:	gestational choriocarcinoma
Category:	Disease Ontology
Type:		Neoplasms
Define:	A choriocarcicoma that develops in the presence of a preceding gestational event.
Alias:	Gestational chorionepithelioma//Molar pregnancy with choriocarcinoma

Disease Association Statistics

Total Associated ncRNA Number:

2 More Information

Causal ncRNA Number:

Network:

Top Causal ncRNAs:

CBR3-AS1 (Score: 0.731059)

More Information

Evidence Support

Strong Evidence:	RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay
Weak Evidence:

Reference

[1] PubMed ID:	35655916
Disease Name:	gestational choriocarcinoma
Sample:	GC cells
Dysfunction Pattern:	Interaction(PTBP1/SETD4 )
Validated Method:	RNA Pull-Down//Western Blot//CCK8//qRT-PCR//Flow Cytometry//Colony Formation Assay
Description:	CBR3-AS1 was markedly upregulated in GC cells, and its downregulation suppressed cell proliferation, induced cell cycle arrest, but promoted cell apoptosis in GC. . SETD4 was determined as the downstream mRNA of CBR3-AS1 and positively regulated by CBR3-AS1 in GC cells. Furthermore, CBR3-AS1 could interact with its RNA binding protein (RBP) PTBP1, thereby stabilizing SETD4 mRNA. Rescue assays verified that CBR3-AS1 facilitates GC cell malignant proliferation via SETD4.
Causality:	Yes
Causal Description:	CBR3-AS1 was markedly upregulated in GC cells, and its downregulation suppressed cell proliferation, induced cell cycle arrest, but promoted cell apoptosis in GC.
Clinical-realted Application:

LncRNADisease v3.0

Entry Detail