Entry Detail

General Information

Database ID: LDA0004563
Species: Homo sapiens
Confidence Score: 0.985791
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CASC9
Full Name:cancer susceptibility 9
Category:LncRNA
Species:Homo sapiens
Synonyms:ESCCAL-1|ESSCAL1|LINC00981|linc-JPH1
Chromosome:8
Strand:-
Coordinate:
Start Site(bp):75223117End Site(bp):75278889
External Links:
Ensembl ID:ENSG00000249395
Ensembl Transcript ID:N/A
Entrez Gene:101805492.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:40   
More Information
Causal Disease Number:40
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 1)
Breast Neoplasms  (Score: 1)
Esophageal Squamous Cell Carcinoma  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Colorectal Neoplasms  (Score: 1)
Breast Neoplasms  (Score: 1)
Squamous Cell Carcinoma of Head and Neck  (Score: 1)
Urinary Bladder Neoplasms  (Score: 0.999893)
Urinary Bladder Neoplasms  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10534D013274
Disease Name:stomach cancerStomach Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the stomach.Tumors or cancer of the STOMACH.
Alias:gastric cancer//gastric neoplasmStomach Neoplasms//Neoplasm, Stomach//Stomach Neoplasm//Neoplasms, Stomach//Gastric Neoplasms//Gastric Neoplasm//Neoplasm, Gastric//Neoplasms, Gastric//Cancer of Stomach//Stomach Cancers//Gastric Cancer//Cancer, Gastric//Cancers, Gastric//Gastric Cancers//Stomach Cancer//Cancer, Stomach//Cancers, Stomach//Cancer of the Stomach//Gastric Cancer, Familial Diffuse

 

Disease Association Statistics

Total Associated ncRNA Number:1648   
More Information
Causal ncRNA Number:1044
Network:
Top Causal ncRNAs:
NORAD  (Score: 1)
SNHG1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
MALAT1  (Score: 1)
SNHG12  (Score: 1)
DLX6-AS1  (Score: 1)
UCA1  (Score: 1)
SNHG3  (Score: 1)
H19  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP//CCK8//Luciferase Report Assay//Cell Viability Assay//Cell Apoptosis Assay//Cell Cycle Assay//Colony Formation Assay//Invasion Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31642035
Disease Name:Stomach Neoplasms
Sample:GC tissues and cell lines
Dysfunction Pattern:Interaction[Regulating BMI1]
Validated Method:RNA Pull-Down//Western Blot//Flow Cytometry//qRT-PCR//RIP
Description:LncRNA CASC9 was upregulated in GC tissue and GC cells.LncRNA CASC9 could interact with BMI1 and positively regulate BMI1 expression. Silencing CASC9 promoted the ubiquitination of BMI1. In addition, lncRNA CASC9 regulated the apoptosis of GC cells through BMI1. Furthermore, interfering CASC9 inhibited the tumor growth of GC. LncRNA CASC9 could interact with BMI1 to regulate the degradation of BMI1, thus to affect the apoptosis of GC cells and suppressed tumor growth.
Causality:Yes
Causal Description:Silencing CASC9 promoted the apoptosis of GC cells.
Clinical-realted Application:LncRNA CASC9 was upregulated in GC tissue and GC cells, and high CASC9 expression was positively correlated with TNM stage and lymph node metastasis.

[2] PubMed ID:33478874
Disease Name:Stomach Neoplasms
Sample:Eighty GC tissues and paired adjacent normal tissues
Dysfunction Pattern:Interaction(miR-370/EGFR axis)
Validated Method:In Vivo Experiment//RNA Pull-Down//Western Blot//Bioinformatics Analysis//CCK8//qRT-PCR//Luciferase Report Assay//Cell Viability Assay//Cell Apoptosis Assay//Cell Cycle Assay//Colony Formation Assay//Invasion Assay
Description: Our results showed that CASC9 was up-regulated significantly in both GC tissues and cell lines. Further analysis indicated that CASC9 directly targeted miR-370 and negatively regulated miR-370 expression in GC. Besides, EGFR (epidermal growth factor receptor) was identified as a direct target gene of miR-370.
Causality:Yes
Causal Description:Conversely, CASC9 knockdown inhibited GC growth in vitro.
Clinical-realted Application: