Entry Detail

General Information

Database ID: LDA0004585
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CASC2
Full Name:cancer susceptibility 2
Category:LncRNA
Species:Homo sapiens
Synonyms:C10orf5
Chromosome:10
Strand:+
Coordinate:
Start Site(bp):118046821End Site(bp):118210153
External Links:
Ensembl ID:ENSG00000177640
Ensembl Transcript ID:N/A
Entrez Gene:255082.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:70   
More Information
Causal Disease Number:60
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Pancreatic Neoplasms  (Score: 0.999893)
Pancreatic Neoplasms  (Score: 0.999893)
Colonic Neoplasms  (Score: 0.985791)
Colonic Neoplasms  (Score: 0.985791)
Thyroid Neoplasms  (Score: 0.985791)
Sepsis  (Score: 0.985791)
Thyroid Neoplasms  (Score: 0.985791)
Arthritis, Rheumatoid  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D055371
Disease Name:Acute Lung Injury
Category:MeSH
Type:Respiratory Tract Diseases
Define:A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).
Alias:Acute Lung Injury//Acute Lung Injuries//Lung Injuries, Acute//Lung Injury, Acute

 

Disease Association Statistics

Total Associated ncRNA Number:16   
More Information
Causal ncRNA Number:12
Network:
Top Causal ncRNAs:
H19  (Score: 0.985791)
H19  (Score: 0.985791)
Malat1  (Score: 0.731059)
MALAT1  (Score: 0.731059)
CASC2  (Score: 0.731059)
hsa_circ_0001679  (Score: 0.731059)
hsa_circ_0054633  (Score: 0.731059)
Malat1  (Score: 0.731059)
MALAT1  (Score: 0.731059)
CASC2  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//ELISA
Weak Evidence:

 

Reference

[1] PubMed ID:34165388
Disease Name:Acute Lung Injury
Sample:Serum specimens
Dysfunction Pattern:Interaction(miR-152-3p/PDK4 Axis)
Validated Method:RNA Pull-Down//Western Blot//Transfection//Flow Cytometry//qRT-PCR//RIP//Luciferase Report Assay//Cell Proliferation Assay//ELISA
Description:CASC2 and PDK4 were down-regulated, while miR-152-3p was up-regulated in sepsis patients and LPS-stimulated HPAEpiC. In addition, miR-152-3p was a miRNA target of CASC2 and CASC2 alleviated cell injury in LPS-disposed HPAEpiC by sponging miR-152-3p. Moreover, miR-152-3p directly targeted PDK4 and CASC2 increased the PDK4 expression by depending on the sponge effect on miR-152-3p.
Causality:Yes
Causal Description:Overexpression of CASC2 relieved the LPS-resulted cell viability inhibition, apoptosis promotion, inflammatory and oxidative damages in HPAEpiC.
Clinical-realted Application: