Entry Detail

General Information

Database ID: LDA0004586
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CASC2
Full Name:cancer susceptibility 2
Category:LncRNA
Species:Homo sapiens
Synonyms:C10orf5
Chromosome:10
Strand:+
Coordinate:
Start Site(bp):118046821End Site(bp):118210153
External Links:
Ensembl ID:ENSG00000177640
Ensembl Transcript ID:N/A
Entrez Gene:255082.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:70   
More Information
Causal Disease Number:60
Network:
Top Causal Diseases:
Carcinoma, Hepatocellular  (Score: 1)
Carcinoma, Hepatocellular  (Score: 1)
Pancreatic Neoplasms  (Score: 0.999893)
Pancreatic Neoplasms  (Score: 0.999893)
Colonic Neoplasms  (Score: 0.985791)
Colonic Neoplasms  (Score: 0.985791)
Thyroid Neoplasms  (Score: 0.985791)
Sepsis  (Score: 0.985791)
Thyroid Neoplasms  (Score: 0.985791)
Arthritis, Rheumatoid  (Score: 0.985791)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:D058186
Disease Name:Acute Kidney Injury
Category:MeSH
Type:Urogenital Diseases
Define:Abrupt reduction in kidney function. Acute kidney injury encompasses the entire spectrum of the syndrome including acute kidney failure; ACUTE KIDNEY TUBULAR NECROSIS; and other less severe conditions.
Alias:Acute Kidney Injury//Acute Kidney Injuries//Kidney Injuries, Acute//Kidney Injury, Acute//Acute Renal Injury//Acute Renal Injuries//Renal Injuries, Acute//Renal Injury, Acute//Renal Insufficiency, Acute//Acute Renal Insufficiencies//Renal Insufficiencies, Acute//Acute Renal Insufficiency//Kidney Insufficiency, Acute//Acute Kidney Insufficiencies//Kidney Insufficiencies, Acute//Acute Kidney Insufficiency//Kidney Failure, Acute//Acute Kidney Failures//Kidney Failures, Acute//Acute Renal Failure//Acute Renal Failures//Renal Failures, Acute//Renal Failure, Acute//Acute Kidney Failure

 

Disease Association Statistics

Total Associated ncRNA Number:30   
More Information
Causal ncRNA Number:30
Network:
Top Causal ncRNAs:
NEAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
NEAT1  (Score: 0.985791)
MALAT1  (Score: 0.985791)
PVT1  (Score: 0.731059)
Kcnq1ot1  (Score: 0.731059)
H19  (Score: 0.731059)
CASC2  (Score: 0.731059)
SNHG14  (Score: 0.731059)
hsa_circ_0020339  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay
Weak Evidence:

 

Reference

[1] PubMed ID:33957574
Disease Name:Acute Kidney Injury
Sample:sepsis patients' serums and LPS-treated HK2 and HEK293 cells
Dysfunction Pattern:Interaction(MiR-545-3p/PPARA Axis)
Validated Method:Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//Flow Cytometry//Luciferase Report Assay
Description: CASC2 level was decreased in sepsis patients' serums and LPS-treated HK2 and HEK293 cells.CASC2 was identified as a sponge for miR-545-3p to regulate PPARA expression. MiR-545-3p overexpression restored the impact of CASC2 on LPS-induced injury in HK2 and HEK293 cells. Moreover, miR-545-3p overexpression aggravated LPS-induced cell injury in HK2 and HEK293 cells by targeting PPARA.
Causality:Yes
Causal Description:CASC2 overexpression facilitated cell viability and restrained cell apoptosis, migration, epithelial-mesenchymal transition (EMT) and oxidative stress in LPS-triggered HK2 and HEK293 cells.
Clinical-realted Application: