Entry Detail

General Information

Database ID: LDA0004591
Species: Homo sapiens
Confidence Score: 0.999893
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:CASC21
Full Name:cancer susceptibility 21
Category:LncRNA
Species:Homo sapiens
Synonyms:CARLO2|CARLo-2|LINC01244
Chromosome:8
Strand:+
Coordinate:
Start Site(bp):127244637End Site(bp):127392631
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:103021164.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.999893)
Colorectal Neoplasms  (Score: 0.999893)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9256D015179
Disease Name:colorectal cancerColorectal Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A large intestine cancer that is located_in the colon and/or located_in the rectum.Tumors or cancer of the COLON or the RECTUM or both. Risk factors for colorectal cancer include chronic ULCERATIVE COLITIS; FAMILIAL POLYPOSIS COLI; exposure to ASBESTOS; and irradiation of the CERVIX UTERI.
Alias:Colorectal Neoplasms//Colorectal Neoplasm//Neoplasm, Colorectal//Neoplasms, Colorectal//Colorectal Tumors//Colorectal Tumor//Tumor, Colorectal//Tumors, Colorectal//Colorectal Cancer//Cancer, Colorectal//Cancers, Colorectal//Colorectal Cancers//Colorectal Carcinoma//Carcinoma, Colorectal//Carcinomas, Colorectal//Colorectal Carcinomas

 

Disease Association Statistics

Total Associated ncRNA Number:1274   
More Information
Causal ncRNA Number:984
Network:
Top Causal ncRNAs:
TP73-AS1  (Score: 1)
PVT1  (Score: 1)
UCA1  (Score: 1)
TUG1  (Score: 1)
ZFAS1  (Score: 1)
XIST  (Score: 1)
SNHG6  (Score: 1)
MEG3  (Score: 1)
HOTTIP  (Score: 1)
MCM3AP-AS1  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//IHC//ChIP//Western Blot//Wound Healing Assay//CCK8//Flow Cytometry//qRT-PCR//RIP//IF//Luciferase Report Assay//Colony Formation Assay//EdU Staining//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:31731190
Disease Name:Colorectal Neoplasms
Sample:colorectal cancer tissues
Dysfunction Pattern:Regulation[miR-7-5p/YAP1 axis]
Validated Method:Western Blot//Wound Healing Assay//CCK8//Flow Cytometry//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description:By bioinformatics analysis, CASC21 was found to be significantly up-regulated in colorectal cancer tissues.Mechanistically, CASC21 could competently bind to miR-7-5p, resulting in increased YAP1 expression. Furthermore, up-regulation of YAP1 could rescue the inhibitory effects of CASC21 knockdown on EMT and cell invasion.
Causality:Yes
Causal Description: Moreover, CASC21 knockdown displayed significant depression in cell viability, proliferation, migration, and invasion in colorectal cancer cells, as well as EMT process, while cell apoptosis was promoted by regulating the Bcl-2/Bax axis and Caspase cascade.
Clinical-realted Application:

[2] PubMed ID:32584787
Disease Name:Colorectal Neoplasms
Sample:colorectal cancer tissues
Dysfunction Pattern:regulation[regulating CDK6]
Validated Method:CCK8//qRT-PCR//RIP//Luciferase Report Assay//Colony Formation Assay//EdU Staining//ChIP
Description:CASC21 is overexpressed in CRC and high CASC21 expression is associated with poor survival.Mechanistically, we found that CASC21 expressed predominantly in the cytoplasm. CASC21 could interact with miR-539-5p and regulate its target CDK6.
Causality:Yes
Causal Description:Functional experiments revealed that CASC21 promotes CRC cell growth.
Clinical-realted Application:CASC21 is overexpressed in CRC and high CASC21 expression is associated with poor survival.

[3] PubMed ID:34375566
Disease Name:Colorectal Neoplasms
Sample:CRC cell
Dysfunction Pattern:Interaction(miR-485-5p/POU5F1B)
Validated Method:RNA Pull-Down//qRT-PCR//RIP//IF//Luciferase Report Assay//IHC//ChIP
Description: In addition, CASC21 was co-expressed with and bound to transcription factor POU5F1B (POU class 5 homeobox 1B). CASC21 recruited POU5F1B to HGH1 promoter to activate the transcription of HGH1 homolog. Also, CASC21 served as a competitive endogenous RNA (ceRNA) to up-regulate HGH1 via endogenously sponging miR-485-5p.
Causality:Yes
Causal Description:The results revealed that CASC21 facilitated CRC cell proliferation, migration, epithelial-mesenchymal transition (EMT) and stemness.
Clinical-realted Application: