Entry Detail

General Information

Database ID: LDA0004604
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:BRE-AS1
Full Name:BABAM2 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:BRE-AS1
Chromosome:2
Strand:-
Coordinate:
Start Site(bp):27889456End Site(bp):27891114
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:100302650.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:10   
More Information
Causal Disease Number:8
Network:
Top Causal Diseases:
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
prostate carcinoma  (Score: 0.731059)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Urinary Bladder Neoplasms  (Score: 0.731059)
Triple Negative Breast Neoplasms  (Score: 0.731059)
prostate carcinoma  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10286
Disease Name:prostate carcinoma
Category:Disease Ontology
Type:Neoplasms
Define:A prostate cancer that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.
Alias:cancer of prostate//carcinoma of prostate

 

Disease Association Statistics

Total Associated ncRNA Number:26   
More Information
Causal ncRNA Number:26
Network:
Top Causal ncRNAs:
PCBP2-OT1  (Score: 0.731059)
FGF14-AS2  (Score: 0.731059)
Erbb4-IR  (Score: 0.731059)
GAS5  (Score: 0.731059)
GASAL1  (Score: 0.731059)
BRE-AS1  (Score: 0.731059)
SNHG16  (Score: 0.731059)
hsa_circ_0102485  (Score: 0.731059)
MIR4435-2HG  (Score: 0.731059)
ZNF667-AS1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//PCR
Weak Evidence:

 

Reference

[1] PubMed ID:30833361
Disease Name:prostate carcinoma
Sample:prostate carcinoma tissues
Dysfunction Pattern:Interaction[miR-145-5p]
Validated Method:CCK8//PCR
Description:In the present study we found that plasma BRE-AS1 and miR-145-5p were both down-regulated in PC patients than in healthy controls.BRE-AS1 overexpression mediated miR-145-5p Expression[up-expression]-regulation in PC cells, while miR-145-5p overexpression did not significantly affect BRE-AS1. miR-145-5p inhibitor attenuated the effects of BRE-AS1 overexpression on cancer cell behaviors.
Causality:Yes
Causal Description:Overexpression of BRE-AS1 and miR-145-5p led to inhibited proliferation and promoted apoptosis of PC cells.
Clinical-realted Application:Down-regulation of BRE-AS1 and miR-145-5p effectively distinguished early-stage PC patients from healthy controls.