Entry Detail

General Information

Database ID: LDA0004632
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:BANCR
Full Name:BRAF-activated non-protein coding RNA
Category:LncRNA
Species:Homo sapiens
Synonyms:LINC00586
Chromosome:9
Strand:-
Coordinate:
Start Site(bp):69296681End Site(bp):69307056
External Links:
Ensembl ID:ENSG00000278910
Ensembl Transcript ID:N/A
Entrez Gene:100885775.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:26   
More Information
Causal Disease Number:18
Network:
Top Causal Diseases:
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Esophageal Squamous Cell Carcinoma  (Score: 0.985791)
Breast Neoplasms  (Score: 0.985791)
Pancreatic Neoplasms  (Score: 0.985791)
Squamous Cell Carcinoma of Head and Neck  (Score: 0.985791)
Carcinoma, Non-Small-Cell Lung  (Score: 0.731059)
Polycystic Ovary Syndrome  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:11612D011085
Disease Name:polycystic ovary syndromePolycystic Ovary Syndrome
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An ovarian dysfunction that is characterized by hyperandrogenism, polycystic ovaries, hirsutism, oligomenorrhea or amenorrhea, anovulation and excessive body weight.A complex disorder characterized by infertility, HIRSUTISM; OBESITY; and various menstrual disturbances such as OLIGOMENORRHEA; AMENORRHEA; ANOVULATION. Polycystic ovary syndrome is usually associated with bilateral enlarged ovaries studded with atretic follicles, not with cysts. The term, polycystic ovary, is misleading.
Alias:Multicystic ovaries//PCOS//Polycystic Ovarian disease//Polycystic ovaries//Stein-Leventhal synd.//Stein-Leventhal syndrome//polycystic ovaryPolycystic Ovary Syndrome//Ovary Syndrome, Polycystic//Syndrome, Polycystic Ovary//Stein-Leventhal Syndrome//Stein Leventhal Syndrome//Syndrome, Stein-Leventhal//Sclerocystic Ovarian Degeneration//Ovarian Degeneration, Sclerocystic//Sclerocystic Ovary Syndrome//Polycystic Ovarian Syndrome//Ovarian Syndrome, Polycystic//Polycystic Ovary Syndrome 1//Sclerocystic Ovaries//Ovary, Sclerocystic//Sclerocystic Ovary

 

Disease Association Statistics

Total Associated ncRNA Number:126   
More Information
Causal ncRNA Number:34
Network:
Top Causal ncRNAs:
hsa_circ_0043532  (Score: 0.985791)
hsa_circ_0043532  (Score: 0.985791)
MALAT1  (Score: 0.731059)
BANCR  (Score: 0.731059)
LINC00477  (Score: 0.731059)
lncROR  (Score: 0.731059)
H19  (Score: 0.731059)
lnc-CCNL1-3:1  (Score: 0.731059)
GAS5  (Score: 0.731059)
lnc-MAP3K13-7:1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:CCK8//qRT-PCR//MTT//Western Blot
Weak Evidence:

 

Reference

[1] PubMed ID:30592281
Disease Name:Polycystic Ovary Syndrome
Sample:granulosa cells
Dysfunction Pattern:Interaction[upregulation of Bax and p53]
Validated Method:CCK8//qRT-PCR//MTT//Western Blot
Description:The results revealed that the expression levels of lncRNA BANCR in GCs were significantly higher in patients with PCOS compared with in non‑PCOS patients.Transfection with the BANCR expression vector significantly inhibited proliferation and promoted apoptosis of KGN cells, and significantly promoted the expression levels of pro‑apoptotic Bax and p53.
Causality:Yes
Causal Description:Transfection with the BANCR expression vector significantly inhibited proliferation and promoted apoptosis of KGN cells, and significantly promoted the expression levels of pro‑apoptotic Bax and p53.
Clinical-realted Application: