LncRNADisease3

Entry Detail

General Information

Database ID:	LDA0004646
Species:	Homo sapiens
Confidence Score:	0.731059
Contents:	>> ncRNA Information >> ncRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference
Causality:	Yes
Clinical Significance:	Unknown

ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:

ASB16-AS1

Full Name:

ASB16 antisense RNA 1

Category:

LncRNA

Species:

Homo sapiens

Synonyms:

C17orf65

Chromosome:

Strand:

Coordinate:

Start Site(bp):

44175973

End Site(bp):

44186717

External Links:

Ensembl ID:	ENSG00000267080
Ensembl Transcript ID:	N/A
Entrez Gene:	339201.0
NONCODE ID:	N/A
RefSeq Accession:	N/A

ncRNA Association Statistics

Total Associated Disease Number:

16 More Information

Causal Disease Number:

Network:

Top Causal Diseases:

Colorectal Neoplasms (Score: 0.985791)

Stomach Neoplasms (Score: 0.731059)

Esophageal Neoplasms (Score: 0.731059)

Uterine Cervical Neoplasms (Score: 0.731059)

Glioma (Score: 0.731059)

Carcinoma, Renal Cell (Score: 0.731059)

Adrenocortical Carcinoma (Score: 0.731059)

Carcinoma, Hepatocellular (Score: 0.731059)

Stomach Neoplasms (Score: 0.731059)

More Information

Disease Information

	Disease Ontology	MeSH
Disease ID:	DOID:5041	D004938
Disease Name:	esophageal cancer	Esophageal Neoplasms
Category:	Disease Ontology	MeSH
Type:		Neoplasms
Define:	A gastrointestinal system cancer that is located_in the esophagus.	Tumors or cancer of the ESOPHAGUS.
Alias:	Ca lower third oesophagus//Ca middle third oesophagus//esophagus cancer//malignant neoplasm of distal third of esophagus//malignant neoplasm of lower third of oesophagus//malignant neoplasm of middle third of oesophagus//malignant neoplasm of proximal third of esophagus//malignant neoplasm of upper third esophagus//malignant tumor of Distal Third of esophagus//malignant tumor of Proximal Third of esophagus//malignant tumor of abdominal esophagus//malignant tumor of the middle Third of the esophagus	Esophageal Neoplasms//Esophageal Neoplasm//Neoplasm, Esophageal//Esophagus Neoplasm//Esophagus Neoplasms//Neoplasm, Esophagus//Neoplasms, Esophagus//Neoplasms, Esophageal//Cancer of Esophagus//Cancer of the Esophagus//Esophagus Cancer//Cancer, Esophagus//Cancers, Esophagus//Esophagus Cancers//Esophageal Cancer//Cancer, Esophageal//Cancers, Esophageal//Esophageal Cancers

Disease Association Statistics

Total Associated ncRNA Number:

202 More Information

Causal ncRNA Number:

148

Network:

Top Causal ncRNAs:

UCA1 (Score: 0.999893)

ADAMTS9-AS2 (Score: 0.985791)

circPRKCI (Score: 0.731059)

hsa_circ_0006168 (Score: 0.731059)

hsa_circ_0008717 (Score: 0.731059)

hsa_circ_0023397 (Score: 0.731059)

LINC01234 (Score: 0.731059)

LINC00963 (Score: 0.731059)

More Information

Evidence Support

Strong Evidence:	qRT-PCR//MTT
Weak Evidence:

Reference

[1] PubMed ID:	34289570
Disease Name:	Esophageal Neoplasms
Sample:	esophageal cancer tissues
Dysfunction Pattern:	Interaction(miR-1258)
Validated Method:	qRT-PCR//MTT
Description:	The expression levels of ASB16-AS1 and miR-1258 in esophageal cancer tissues were 2.95±0.27 and 0.62±0.06, respectively. ASB16-AS1 targeted negative regulation of miR-1258 expression.
Causality:	Yes
Causal Description:	The cell viability of the si-NC group at 48 h and 72 h were 0.81±0.07 and 1.15±0.11, while those of si-ASB16-AS1 group were 0.46±0.04 and 0.62±0.06 (P<0.05). The numbers of cell migration and invasion in the si-NC group were 86.32±8.24 and 71.29±7.15, respectively, while those of si-ASB16-AS1 group were 43.22±4.31 and 32.36±3.58, respectively, the differences were statistically significant (P<0.05). The cell viability of the miR-NC group at 48 h and 72 h were 0.84±0.08, 1.18±0.12, while those of miR-1258 group were 0.55±0.05, 0.71±0.07 (P<0.05). The migration and invasion numbers of the miR-NC group were (83.15±8.31) and (75.33±7.51), while those of miR-1258 group were (49.58±4.23) and (38.42±3.84), respectively, the differences were statistically significant (P<0.05). The cell viability of the si-ASB16-AS1+ anti-miR-NC group at 48 h and 72 h were 0.45±0.04, 0.61±0.06, while those of si-ASB16-AS1+ anti-miR-1258 group were 0.72±0.07, 0.98±0.08; The migration and invasion numbers of cells in the si-ASB16-AS1+ anti-miR-NC group were 44.36±4.41 and 31.69±3.85, respectively, while those of si-ASB16-AS1+ anti-miR-1258 group were 72.65±7.27 and 61.22±6.14, respectively, and the differences were statistically significant (P<0.05).
Clinical-realted Application:

LncRNADisease v3.0

Entry Detail