Entry Detail

General Information

Database ID: LDA0004647
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ASB16-AS1
Full Name:ASB16 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:C17orf65
Chromosome:17
Strand:-
Coordinate:
Start Site(bp):44175973End Site(bp):44186717
External Links:
Ensembl ID:ENSG00000267080
Ensembl Transcript ID:N/A
Entrez Gene:339201.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Adrenocortical Carcinoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:4362D002583
Disease Name:cervical cancerUterine Cervical Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A female reproductive organ cancer that is located_in the cervix.Tumors or cancer of the UTERINE CERVIX.
Alias:cervical neoplasm//cervix cancer//cervix uteri cancer//neoplasm of uterine cervix//tumor of the Cervix Uteri//uterine cervical neoplasmUterine Cervical Neoplasms//Cervical Neoplasm, Uterine//Neoplasm, Uterine Cervical//Uterine Cervical Neoplasm//Neoplasms, Cervical//Cervical Neoplasms//Cervical Neoplasm//Neoplasms, Cervix//Cervix Neoplasm//Neoplasm, Cervix//Cervix Neoplasms//Cancer of the Uterine Cervix//Cancer of the Cervix//Cervical Cancer//Cancer, Cervical//Cervical Cancers//Uterine Cervical Cancer//Cancer, Uterine Cervical//Cervical Cancer, Uterine//Uterine Cervical Cancers//Cancer of Cervix//Cervix Cancer//Cancer, Cervix

 

Disease Association Statistics

Total Associated ncRNA Number:15334   
More Information
Causal ncRNA Number:532
Network:
Top Causal ncRNAs:
UCA1  (Score: 1)
CRNDE  (Score: 1)
WT1-AS  (Score: 1)
PVT1  (Score: 1)
LINC00511  (Score: 1)
DARS1-AS1  (Score: 1)
UCA1  (Score: 1)
NEAT1  (Score: 1)
OIP5-AS1  (Score: 1)
CRNDE  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:32058219
Disease Name:Uterine Cervical Neoplasms
Sample:CC tissues and CC cells
Dysfunction Pattern:regulation[miR-1305/Wnt/β-catenin axis ]
Validated Method:Western Blot//CCK8//qRT-PCR//Luciferase Report Assay//Colony Formation Assay//Transwell Assay
Description: In our study, we showed that the expression of ASB16-AS1 was increased while miR-1305 reduced was re in CC.This study reveals that ASB16-AS1 promotes cell proliferation, migration, invasion via binding miR-1305 with Wnt2, and enhancing the Wnt/β-catenin pathway. ASB16-AS1 may play a new therapeutic target for CC.
Causality:Yes
Causal Description:Knockdown of ASB16-AS1 reduced CC cells proliferation, migration and invasion abilities by regulating miR-1305 in vitro and in vivo.
Clinical-realted Application:Clinically, ASB16-AS1 and miR-1305 were correlated with poor-associated clinicopathological features of CC patients.