Entry Detail

General Information

Database ID: LDA0004650
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ASB16-AS1
Full Name:ASB16 antisense RNA 1
Category:LncRNA
Species:Homo sapiens
Synonyms:C17orf65
Chromosome:17
Strand:-
Coordinate:
Start Site(bp):44175973End Site(bp):44186717
External Links:
Ensembl ID:ENSG00000267080
Ensembl Transcript ID:N/A
Entrez Gene:339201.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:16   
More Information
Causal Disease Number:16
Network:
Top Causal Diseases:
Colorectal Neoplasms  (Score: 0.985791)
Colorectal Neoplasms  (Score: 0.985791)
Stomach Neoplasms  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
Uterine Cervical Neoplasms  (Score: 0.731059)
Glioma  (Score: 0.731059)
Carcinoma, Renal Cell  (Score: 0.731059)
Adrenocortical Carcinoma  (Score: 0.731059)
Carcinoma, Hepatocellular  (Score: 0.731059)
Stomach Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:3948D018268
Disease Name:adrenocortical carcinomaAdrenocortical Carcinoma
Category:Disease OntologyMeSH
Type:Neoplasms
Define:An adrenal cortex cancer that forms in the outer layer of tissue of the adrenal gland and that has_material_basis_in abnormally proliferating cells derives_from epithelial cells.A malignant neoplasm of the ADRENAL CORTEX. Adrenocortical carcinomas are unencapsulated anaplastic (ANAPLASIA) masses sometimes exceeding 20 cm or 200 g. They are more likely to be functional than nonfunctional, and produce ADRENAL CORTEX HORMONES that may result in hypercortisolism (CUSHING SYNDROME); HYPERALDOSTERONISM; and/or VIRILISM.
Alias:Adrenal cortical carcinoma//carcinoma of the Adrenal cortexAdrenocortical Carcinoma//Adrenocortical Carcinomas//Carcinomas, Adrenocortical//Carcinoma, Adrenocortical//Carcinoma, Adrenal Cortical//Adrenal Cortical Carcinoma//Adrenal Cortical Carcinomas//Carcinomas, Adrenal Cortical

 

Disease Association Statistics

Total Associated ncRNA Number:30   
More Information
Causal ncRNA Number:6
Network:
Top Causal ncRNAs:
H19  (Score: 0.731059)
ASB16-AS1  (Score: 0.731059)
circCCAC1  (Score: 0.731059)
H19  (Score: 0.731059)
ASB16-AS1  (Score: 0.731059)
circCCAC1  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:RNA Pull-Down//ISH//Immunoblotting//CCK8//qRT-PCR//RIP//Cell Cycle Assay//IHC//EdU Staining
Weak Evidence:

 

Reference

[1] PubMed ID:33219221
Disease Name:Adrenocortical Carcinoma
Sample:adrenocortical carcinoma tissues
Dysfunction Pattern:regulation[HuR]
Validated Method:RNA Pull-Down//ISH//Immunoblotting//CCK8//qRT-PCR//RIP//RNA-seq//Cell Cycle Assay//IHC//EdU Staining
Description:Here, we found that lncRNA ASB16-AS1 was down-regulated in adrenocortical carcinoma and ASB16-AS1 functions as tumor suppressor in vitro and in vivo. We then found that inhibition of ASB16-AS1 attenuates the binding of ubiquitin E3 ligase BTRC to HuR and subsequently inhibits HuR protein unbiquitination and degradation. BTRC knock-down could reverse the effect of AB16-AS1 on HuR, CDK6, and IGF1R levels.
Causality:Yes
Causal Description:Here, we found that lncRNA ASB16-AS1 was down-regulated in adrenocortical carcinoma and ASB16-AS1 functions as tumor suppressor in vitro and in vivo.
Clinical-realted Application: