Entry Detail

General Information

Database ID: LDA0004656
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Yes

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:AS1
Full Name:prostaglandin D2 receptor
Category:LncRNA
Species:Homo sapiens
Synonyms:AS1|ASRT1|DP|DP1|PTGDR1
Chromosome:14
Strand:+
Coordinate:
Start Site(bp):52267698End Site(bp):52280914
External Links:
Ensembl ID:N/A
Ensembl Transcript ID:N/A
Entrez Gene:5729.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Prostatic Neoplasms  (Score: 0.731059)
Prostatic Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:10283D011471
Disease Name:prostate cancerProstatic Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A male reproductive organ cancer that is located_in the prostate.Tumors or cancer of the PROSTATE.
Alias:NGP - new growth of prostate//hereditary prostate cancer//malignant tumor of the prostate//prostate cancer, familial//prostate neoplasm//prostatic cancer//prostatic neoplasm//tumor of the prostateProstatic Neoplasms//Prostate Neoplasms//Neoplasms, Prostate//Neoplasm, Prostate//Prostate Neoplasm//Neoplasms, Prostatic//Neoplasm, Prostatic//Prostatic Neoplasm//Prostate Cancer//Cancer, Prostate//Cancers, Prostate//Prostate Cancers//Cancer of the Prostate//Prostatic Cancer//Cancer, Prostatic//Cancers, Prostatic//Prostatic Cancers//Cancer of Prostate

 

Disease Association Statistics

Total Associated ncRNA Number:566   
More Information
Causal ncRNA Number:414
Network:
Top Causal ncRNAs:
TUG1  (Score: 1)
SNHG1  (Score: 1)
MALAT1  (Score: 1)
NORAD  (Score: 1)
NEAT1  (Score: 1)
circHIPK3  (Score: 1)
SNHG3  (Score: 1)
MALAT1  (Score: 1)
SNHG1  (Score: 1)
NORAD  (Score: 1)
More Information

 

Evidence Support

Strong Evidence:Cell Cycle Assay//qPCR//Western Blot//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:34151833
Disease Name:Prostatic Neoplasms
Sample:prostate cells and prostate cancer cells (PCCs)
Dysfunction Pattern:Expression(highly expressed)
Validated Method:Cell Cycle Assay//qPCR//Transwell Assay//Western Blot
Description:LncRNA NCK1-AS1 is highly expressed in PCa, so its down-regulation can inhibit PCCs from proliferating and reduce the number of invasive cells.
Causality:Yes
Causal Description:Compared with the Blank group, cell proliferation and the number of plate cloned cells remarkably reduced in the sh-NCK1-AS1 group.
Clinical-realted Application:The prognosis of patients with high LncRNA NCK1-AS1 expression was remarkably poorer than that of those with low expression.