Entry Detail

General Information

Database ID: LDA0004675
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:ATAD1
Full Name:ATPase family AAA domain containing 1
Category:LncRNA
Species:Homo sapiens
Synonyms:AFDC1|FNP001|HKPX4|Msp1|THORASE|hATAD1
Chromosome:10
Strand:-
Coordinate:
Start Site(bp):87751512End Site(bp):87841361
External Links:
Ensembl ID:ENSG00000283024
Ensembl Transcript ID:N/A
Entrez Gene:84896.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Leukemia, Myeloid, Acute  (Score: 0.731059)
Leukemia, Myeloid, Acute  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:9119D015470
Disease Name:acute myeloid leukemiaLeukemia, Myeloid, Acute
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A myeloid leukemia that is characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells.Clonal expansion of myeloid blasts in bone marrow, blood, and other tissue. Myeloid leukemias develop from changes in cells that normally produce NEUTROPHILS; BASOPHILS; EOSINOPHILS; and MONOCYTES.
Alias:AML - acute Myeloid Leukemia//Leukemia, Myelocytic, acute//acute myeloblastic leukaemia//acute myeloblastic leukemia//acute myelogenous leukaemia//acute myelogenous leukemia//acute myeloid leukaemiaLeukemia, Myeloid, Acute//Acute Myeloid Leukemia//Acute Myeloid Leukemias//Leukemias, Acute Myeloid//Myeloid Leukemias, Acute//ANLL//Leukemia, Acute Myelogenous//Leukemia, Acute Myeloid//Leukemia, Myeloblastic, Acute//Leukemia, Myelocytic, Acute//Leukemia, Myelogenous, Acute//Leukemia, Nonlymphoblastic, Acute//Leukemia, Nonlymphocytic, Acute//Myeloblastic Leukemia, Acute//Acute Myeloblastic Leukemia//Acute Myeloblastic Leukemias//Leukemia, Acute Myeloblastic//Leukemias, Acute Myeloblastic//Myeloblastic Leukemias, Acute//Myelocytic Leukemia, Acute//Acute Myelocytic Leukemia//Acute Myelocytic Leukemias//Leukemia, Acute Myelocytic//Leukemias, Acute Myelocytic//Myelocytic Leukemias, Acute//Myelogenous Leukemia, Acute//Myeloid Leukemia, Acute//Nonlymphoblastic Leukemia, Acute//Acute Nonlymphoblastic Leukemia//Acute Nonlymphoblastic Leukemias//Leukemia, Acute Nonlymphoblastic//Leukemias, Acute Nonlymphoblastic//Nonlymphoblastic Leukemias, Acute//Nonlymphocytic Leukemia, Acute//Acute Nonlymphocytic Leukemia//Acute Nonlymphocytic Leukemias//Leukemia, Acute Nonlymphocytic//Leukemias, Acute Nonlymphocytic//Nonlymphocytic Leukemias, Acute//Acute Myelogenous Leukemia//Acute Myelogenous Leukemias//Leukemias, Acute Myelogenous//Myelogenous Leukemias, Acute//Myeloid Leukemia, Acute, M1//Leukemia, Myeloid, Acute, M1//Acute Myeloid Leukemia without Maturation//Leukemia, Myeloid, Acute, M2//Myeloid Leukemia, Acute, M2//Acute Myeloid Leukemia with Maturation

 

Disease Association Statistics

Total Associated ncRNA Number:196   
More Information
Causal ncRNA Number:138
Network:
Top Causal ncRNAs:
SNHG1  (Score: 1)
SNHG1  (Score: 1)
NEAT1  (Score: 1)
NEAT1  (Score: 1)
TUG1  (Score: 0.999998)
TUG1  (Score: 0.999998)
MVIH  (Score: 0.999893)
SNHG5  (Score: 0.999893)
CDKN2B-AS1  (Score: 0.999893)
SNHG5  (Score: 0.999893)
More Information

 

Evidence Support

Strong Evidence:BrdU//qRT-PCR
Weak Evidence:

 

Reference

[1] PubMed ID:34630706
Disease Name:Leukemia, Myeloid, Acute
Sample:patients with AML
Dysfunction Pattern:Interaction(miR-34b)
Validated Method:BrdU//qRT-PCR
Description: circ-ATAD1 expression was found to be elevated, and inversely correlated with that of miR-34b, in patients with AML. In addition, circ-ATAD1 overexpression in AML cells decreased miR-34b expression and increased miR-34b gene methylation.
Causality:Yes
Causal Description:Moreover, AML cell proliferation was increased by circ-ATAD1 overexpression, but decreased by miR-34b overexpression, and the effect of circ-ATAD1 overexpression on AML cell proliferation was reduced by miR-34b overexpression.
Clinical-realted Application: