Entry Detail

General Information

Database ID: LDA0004681
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:BMPR1B-DT
Full Name:BMPR1B divergent transcript
Category:LncRNA
Species:Homo sapiens
Synonyms:BMPR1B-AS1
Chromosome:4
Strand:-
Coordinate:
Start Site(bp):94743668End Site(bp):94757533
External Links:
Ensembl ID:ENSG00000249599
Ensembl Transcript ID:N/A
Entrez Gene:100507012.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Endometrial Neoplasms  (Score: 0.731059)
Endometrial Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:1380D016889
Disease Name:endometrial cancerEndometrial Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A uterine cancer that is located_in tissues lining the uterus.Tumors or cancer of ENDOMETRIUM, the mucous lining of the UTERUS. These neoplasms can be benign or malignant. Their classification and grading are based on the various cell types and the percent of undifferentiated cells.
Alias:endometrial Ca//endometrial neoplasm//malignant endometrial neoplasm//malignant neoplasm of endometrium//neoplasm of endometrium//primary malignant neoplasm of endometrium//tumor of EndometriumEndometrial Neoplasms//Endometrial Neoplasm//Neoplasm, Endometrial//Neoplasms, Endometrial//Endometrial Carcinoma//Carcinoma, Endometrial//Carcinomas, Endometrial//Endometrial Carcinomas//Endometrial Cancer//Cancer, Endometrial//Cancers, Endometrial//Endometrial Cancers//Endometrium Cancer//Cancer, Endometrium//Cancers, Endometrium//Cancer of the Endometrium//Carcinoma of Endometrium//Endometrium Carcinoma//Endometrium Carcinomas//Cancer of Endometrium//Endometrium Cancers

 

Disease Association Statistics

Total Associated ncRNA Number:232   
More Information
Causal ncRNA Number:178
Network:
Top Causal ncRNAs:
DLEU1  (Score: 0.999893)
hsa_circ_0000437  (Score: 0.999893)
hsa_circ_0000437  (Score: 0.999893)
DLEU1  (Score: 0.999893)
hsa_circ_0001776  (Score: 0.985791)
PCAT1  (Score: 0.985791)
hsa_circ_0001776  (Score: 0.985791)
PCAT1  (Score: 0.985791)
hsa_circ_0001610  (Score: 0.985791)
hsa_circ_0075960  (Score: 0.985791)
More Information

 

Evidence Support

Strong Evidence:In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//IHC//Transwell Assay
Weak Evidence:

 

Reference

[1] PubMed ID:35404759
Disease Name:Endometrial Neoplasms
Sample:EC cells
Dysfunction Pattern:Interaction(miR-7-2-3p/DCLK1 axis)
Validated Method:In Vivo Experiment//Western Blot//Wound Healing Assay//qRT-PCR//FISH//Luciferase Report Assay//Cell Apoptosis Assay//Cell Cycle Assay//IHC//Transwell Assay
Description:In this study, we analyzed the RNA transcripts of EC cells from The Cancer Genome Atlas (TCGA) and first reported a novel lncRNA, BMPR1B-AS1, that was more highly expressed in endometrial cancer tissues than in adjacent tissues, and BMPR1B-AS1 could promote endometrial cancer cell proliferation and metastasis. Bioinformatics prediction and experimental results both suggested that BMPR1B-AS1 could modulate the malignant behaviors of endometrial cancer cell lines by sponging miR-7-2-3p to modulate DCLK1, and a DCLK1 inhibitor blocked the activation of the PI3K/Akt/NF-κB signaling pathway.
Causality:Yes
Causal Description: Bioinformatics prediction and experimental results both suggested that BMPR1B-AS1 could modulate the malignant behaviors of endometrial cancer cell lines by sponging miR-7-2-3p to modulate DCLK1, and a DCLK1 inhibitor blocked the activation of the PI3K/Akt/NF-κB signaling pathway.
Clinical-realted Application: