LncRNADisease3

Entry Detail

General Information

Database ID:	LDA0004695
Species:	Homo sapiens
Confidence Score:	0.731059
Contents:	>> ncRNA Information >> ncRNA Association Statistics >> Disease Information >> Disease Association Statistics >> Evidence Support >> Reference
Causality:	Yes
Clinical Significance:	Unknown

ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:

BDNF-AS

Full Name:

BDNF antisense RNA

Category:

LncRNA

Species:

Homo sapiens

Synonyms:

Chromosome:

Strand:

Coordinate:

Start Site(bp):

27506852

End Site(bp):

27698171

External Links:

Ensembl ID:	ENSG00000245573
Ensembl Transcript ID:	N/A
Entrez Gene:	497258.0
NONCODE ID:	N/A
RefSeq Accession:	N/A

ncRNA Association Statistics

Total Associated Disease Number:

8 More Information

Causal Disease Number:

Network:

Top Causal Diseases:

Colorectal Neoplasms (Score: 0.731059)

Glioblastoma (Score: 0.731059)

Multiple Myeloma (Score: 0.731059)

Prostatic Neoplasms (Score: 0.731059)

Colorectal Neoplasms (Score: 0.731059)

Glioblastoma (Score: 0.731059)

Multiple Myeloma (Score: 0.731059)

Prostatic Neoplasms (Score: 0.731059)

More Information

Disease Information

	Disease Ontology	MeSH
Disease ID:	DOID:9538	D009101
Disease Name:	multiple myeloma	Multiple Myeloma
Category:	Disease Ontology	MeSH
Type:		Neoplasms
Define:	A myeloid neoplasm that is located_in the plasma cells in bone marrow.	A malignancy of mature PLASMA CELLS engaging in monoclonal immunoglobulin production. It is characterized by hyperglobulinemia, excess Bence-Jones proteins (free monoclonal IMMUNOGLOBULIN LIGHT CHAINS) in the urine, skeletal destruction, bone pain, and fractures. Other features include ANEMIA; HYPERCALCEMIA; and RENAL INSUFFICIENCY.
Alias:		Multiple Myeloma//Multiple Myelomas//Myelomas, Multiple//Myeloma, Multiple//Myeloma, Plasma-Cell//Myeloma, Plasma Cell//Myelomas, Plasma-Cell//Plasma-Cell Myeloma//Plasma-Cell Myelomas//Myelomatosis//Myelomatoses//Plasma Cell Myeloma//Cell Myeloma, Plasma//Cell Myelomas, Plasma//Myelomas, Plasma Cell//Plasma Cell Myelomas//Kahler Disease//Disease, Kahler//Myeloma-Multiple//Myeloma Multiple//Myeloma-Multiples

Disease Association Statistics

Total Associated ncRNA Number:

180 More Information

Causal ncRNA Number:

Network:

Top Causal ncRNAs:

NEAT1 (Score: 1)

CDKN2B-AS1 (Score: 0.999893)

ST3GAL6-AS1 (Score: 0.999893)

MALAT1 (Score: 0.999893)

ST3GAL6-AS1 (Score: 0.999893)

hsa_circ_0007841 (Score: 0.985791)

lnc-TCF7 (Score: 0.985791)

More Information

Evidence Support

Strong Evidence:	In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//EdU Staining
Weak Evidence:

Reference

[1] PubMed ID:	34980181
Disease Name:	Multiple Myeloma
Sample:	MM serum and corresponding cancer cell lines
Dysfunction Pattern:	Interaction(miR-125a/b-5p-BCL2 axis)
Validated Method:	In Vivo Experiment//Western Blot//Transfection//Wound Healing Assay//CCK8//qRT-PCR//RIP//Luciferase Report Assay//IHC//EdU Staining
Description:	BDNF-AS was significantly upregulated, while miR-125a-5p and miR-125b-5p were downregulated in MM serum and corresponding cancer cell lines. Knockdown of BDNF-AS effectively inhibited the proliferation and migration of MM.1S and U266 cells, and co-transfection of miR-125a-5p or miR-125b-5p inhibitor and sh-BDNF-AS enhanced cell proliferation and migration compared with that in sh-BDNF-AS group. Knockdown of miR-125a-5p or miR-125b-5p significantly enhanced the proliferation and migration of MM.1S and U266 cells, and co-transfection of sh-Bcl-2 and miR-125a/b-5p inhibitor inhibited cell proliferation compared with that in miR-125a/b-5p inhibitor group. Moreover, knockdown of BDNF-AS increased the expression levels of apoptosis-related proteins (cleaved caspase 3 and cleaved PARP), while knockdown of miR-125a-5p or miR-125b-5p reduced the expression levels of these apoptosis-related proteins compared with knockdown of BDNF-AS. Furthermore, knockdown of BDNF-AS effectively suppressed MM tumor growth in vivo.
Causality:	Yes
Causal Description:	Knockdown of BDNF-AS effectively inhibited the proliferation and migration of MM.1S and U266 cells, and co-transfection of miR-125a-5p or miR-125b-5p inhibitor and sh-BDNF-AS enhanced cell proliferation and migration compared with that in sh-BDNF-AS group.
Clinical-realted Application:

LncRNADisease v3.0

Entry Detail