Entry Detail

General Information

Database ID: LDA0004700
Species: Homo sapiens
Confidence Score: 0.731059
Contents: >> ncRNA Information
>> ncRNA Association Statistics
>> Disease Information
>> Disease Association Statistics
>> Evidence Support
>> Reference
Causality: Yes
Clinical Significance: Unknown

 


ncRNA Information

Reference Genome Note: GRCh38 for human lncRNAs; GRCm39 for mouse lncRNAs; mRatBN7.2 for rat lncRNAs; hg19 for human circRNAs; mm9 for mouse circRNAs.

ncRNA Symbol:BMI1
Full Name:BMI1 proto-oncogene, polycomb ring finger
Category:LncRNA
Species:Homo sapiens
Synonyms:FLVI2/BMI1|PCGF4|RNF51|flvi-2/bmi-1
Chromosome:10
Strand:+
Coordinate:
Start Site(bp):22321099End Site(bp):22331484
External Links:
Ensembl ID:ENSG00000168283
Ensembl Transcript ID:N/A
Entrez Gene:648.0
NONCODE ID:N/A
RefSeq Accession:N/A

 

ncRNA Association Statistics

Total Associated Disease Number:2   
More Information
Causal Disease Number:2
Network:
Top Causal Diseases:
Esophageal Neoplasms  (Score: 0.731059)
Esophageal Neoplasms  (Score: 0.731059)
More Information

 

 

Disease Information

 Disease OntologyMeSH
Disease ID:DOID:5041D004938
Disease Name:esophageal cancerEsophageal Neoplasms
Category:Disease OntologyMeSH
Type:Neoplasms
Define:A gastrointestinal system cancer that is located_in the esophagus.Tumors or cancer of the ESOPHAGUS.
Alias:Ca lower third oesophagus//Ca middle third oesophagus//esophagus cancer//malignant neoplasm of distal third of esophagus//malignant neoplasm of lower third of oesophagus//malignant neoplasm of middle third of oesophagus//malignant neoplasm of proximal third of esophagus//malignant neoplasm of upper third esophagus//malignant tumor of Distal Third of esophagus//malignant tumor of Proximal Third of esophagus//malignant tumor of abdominal esophagus//malignant tumor of the middle Third of the esophagusEsophageal Neoplasms//Esophageal Neoplasm//Neoplasm, Esophageal//Esophagus Neoplasm//Esophagus Neoplasms//Neoplasm, Esophagus//Neoplasms, Esophagus//Neoplasms, Esophageal//Cancer of Esophagus//Cancer of the Esophagus//Esophagus Cancer//Cancer, Esophagus//Cancers, Esophagus//Esophagus Cancers//Esophageal Cancer//Cancer, Esophageal//Cancers, Esophageal//Esophageal Cancers

 

Disease Association Statistics

Total Associated ncRNA Number:202   
More Information
Causal ncRNA Number:148
Network:
Top Causal ncRNAs:
UCA1  (Score: 0.999893)
UCA1  (Score: 0.999893)
ADAMTS9-AS2  (Score: 0.985791)
ADAMTS9-AS2  (Score: 0.985791)
circPRKCI  (Score: 0.731059)
hsa_circ_0006168  (Score: 0.731059)
hsa_circ_0008717  (Score: 0.731059)
hsa_circ_0023397  (Score: 0.731059)
LINC01234  (Score: 0.731059)
LINC00963  (Score: 0.731059)
More Information

 

Evidence Support

Strong Evidence:Transfection//qPCR//Proliferation Assay//RIP//Cell Apoptosis Assay//PCR//Cell Proliferation Assay//IP//IF
Weak Evidence:

 

Reference

[1] PubMed ID:34278876
Disease Name:Esophageal Neoplasms
Sample:serum and tissues of esophageal cancer patients
Dysfunction Pattern:Expression [lower expressed]
Validated Method:Transfection//qPCR//Proliferation Assay//RIP//Cell Apoptosis Assay//PCR//Cell Proliferation Assay//IP//IF
Description:Expression of circ-BMI1 in serum and tissues of esophageal cancer patients was significantly decreased compared to controls (P < 0.001 and P = 0.003, respectively). Area under the receiver operating characteristic curve (ROC) was 0.726.
Causality:Yes
Causal Description: Cell proliferation, migration and colony forming ability of circBMI1-Eca109 cells were obviously decreased than that of NC-Eca109 cells (P < 0.05). circBMI1-Eca109 cells were more sensitive to 5-fluorouracil and cisplatin, and tumor volume of nude mice in circBMI1-Eca109 group was smaller (P < 0.05).
Clinical-realted Application: